【摘要】 目的采用3.0T磁敏感加权成像定量测量健康成年人额叶白质区及灰质核团的T2*值,探讨灰质核团与性别的相关性。方法选取年龄25~85岁的128例年龄相匹配的男性组及女性组进行磁共振成像(MRI)常规及磁敏感加权成像(SWI)扫描,经后处理在T2*图像上分别测量左右侧额叶白质区、红核、黑质网状带、黑质致密带、尾状核头、壳核、苍白球和丘脑的T2*值,分析T2*值与性别的相关性。结果男、女性组左、右侧的T2*值在苍白球最低,其次为黑质网状带、红核,额叶白质区的最高。男性组右侧黑质网状带、黑质致密带T2*值小于左侧,女性组右侧黑质网状带T2*值小于左侧(P<0.05)。壳核、丘脑的T2*值男、女性组比较,差异有统计学意义(P<0.05);其余感兴趣区的T2*值比较差异无统计学意义(P>0.05)。结论健康成年人的壳核、丘脑的脑铁含量与性别具有相关性。更多还原

【Abstract】 Objective To quantitatively analyze the iron deposition in deep brain gray nuclei and frontal white matter in healthy population and its correlation with gender using susceptibility-weighted imaging(SWI)with 3.0 Tesla scanner. Methods A total of 128 healthy subjects(64 males and 64 females, aged 25 to 85years) were scanned with routine sequences and SWI sequences by 3.0T MR. T2* value was measured in left and right frontal white matter, red nucleus, substantia nigra pars reticulata, substantia nigra pars compacta,globus pallidus, putamen, head of caudate nucleus and thalamus; the correlations between the T2* value and gender were analyzed. Results The T2*value was the lowest in the globus pallidus, followed by substantia nigra reticulata and red nuclei. The highest T2* value was seen in the frontal white matter. The T2*value of the right substantia nigra compacta and substantia nigra pars reticulata was lower than that of the left-side one in the males(P < 0.05), and the T2* value of the right substantia nigra pars reticulate was lower than that of the left-side one in the females(P < 0.05). The T2* value of putamen and thalamus was significantly different between the males and the females(P < 0.05). Conclusions Using T2* value, a significant correlation has been found between putamen and thalamus iron deposition and gender in health population.更多还原