【摘要】 目的探讨维持性血液透析对慢性肾功能衰竭(CRF)患者C-反应蛋白、白介素-6和脂蛋白(a)的影响。方法以36例进行维持性血液透析的CRF患者为研究对象,36例健康体检者为对照组。分别测定试验初次、3个月后、6个月后、12个月后的每次血液透析前、后的CRP、IL-6和Lp(a)水平。结果 CRF患者血液透析前CRP、IL-6和Lp(a)均显著高于对照组,差异有统计学意义(P<0.05),而每次血液透析前后CRP、IL-6和Lp(a)比较,差异均无统计学意义(P>0.05),试验初次、3个月后、6个月后、12个月后的CRP、IL-6和Lp(a)比较,差异均有统计学意义(P<0.05)。结论 CRF患者普遍存在微炎症状态和高Lp(a)血症,血液透析并不能降低患者的CRP、IL-6和Lp(a)水平,对于维持性血液透析的CRF患者,有必要进行抗炎和降血脂治疗,防止心血管疾病的发生。更多还原

【Abstract】 Objective To study the effects of maintained hemodialysis on C- reactive protein( CRP),interleukin- 6( IL- 6)and lipoprotein( a) [Lp( a) ] in patients with chronic renal failure. Methods 36 cases of CRF patients with maintenance hemodialysis were studied,and 30 healthy persons were served as control group. The levels of CRP,IL- 6 and Lp( a) were measured before and after hemodialysis the first,3 months,6 months,12 months,respectively. Results Before hemodialysis,the level of the serum CRP,IL- 6 and Lp( a) of the patients with chronic renal failure were significantly higher than the control group,and the difference was statistically significant( P < 0. 05). Every time the difference of CRP,IL- 6 and Lp( a) before and after hemodialysis was not statistically significant( P > 0. 05). After the first,3 months,6 months,12 months hemodialysis,the level of the serum CRP,IL- 6 and Lp( a) were statistically significant( P < 0. 05). Conclusion The patients with chronic renal failure were inflammatory state and high lipoprotein hematic disease. Maintained hemodialysis can not reduce the level of CRP,IL- 6 and Lp( a). Anti- inflammatory and reducing lipoprotein( a) were necessary to prevent cardiovascular disease.更多还原