【摘要】 目的了解无锡三院新生儿溶血病(HDN)的发病情况,建立完善的早期产前检查,提高患儿的生存率。方法对2012年9月-2014年1月无锡三院新生儿病房住院患儿临床资料进行回顾性分析,分析男女的发病率,并将其分为正常对照组和HDN患儿组,对比相关因素、确诊试验的阳性率。结果 101例高度疑似HDN新生儿中发病率为24.5%,其中女婴发病率与男婴发病率相似,HDN患儿的网织红细胞、总胆红素、直接胆红素、间接胆红素四种相关因素的结果均明显高于正常对照组(P<0.05)。各种诊断试验中,患儿游离抗体试验、抗体放散试验以及母亲抗体效价(≥1∶128)的检测均有很高的阳性率。结论网织红细胞、胆红素的检测以及患儿红细胞直接抗人球蛋白试验、患儿游离抗体试验、抗体放散试验3种试验对新生儿HDN具有诊断性意义。更多还原

【Abstract】 Objective To comprehend the incidence of hemolytic disease of the newborn(HDN)in the third people’s hospital of Wuxi,and establish prenatal examination to improve the survival rates for HDN newborn.Methods Clinical data of newborns in the third people’s hospital of wuxi(including the HDN incidence rate of male-female)were retrospectively analyzed from 2012.9-2014.1.The newborns were fall into HDN group and control group.The positive rates of diagnosis test and related factors were compared.Results 101 cases of suspected HDN neonatal morbidity rate was24.5%,The incidence was similar between female and male.Four related factors(reticulocyte,total bilirubin,direct bilirubin,indirect bilirubin)of HDN in HDN group were all significant higher than control group(all P<0.05),and the diagnostic tests(including children free antibody test,antibody elution test and maternal antibody titer)positive rates were very high.Conclusion Reticulocyte rates,bilirubin level,red blood cells with direct antiglobulin test,children free antibody test and antibody elution test are significant for HDN diagnosis.更多还原