【摘要】 目的通过分析处于围绝经期的桥本氏甲状腺炎女性患者体内雌激素的变化,探讨围绝经期女性雌激素水平变化与桥本氏甲状腺炎的相关性。方法选取处于围绝经期的桥本氏甲状腺炎女性患者40例,健康围绝经期女性志愿者40例,均在月经第14天检测其体内雌二醇水平。桥本氏甲状腺炎患者的诊断主要依靠甲功三项即FT3、FT4、TSH及甲状腺自身免疫性抗体包括抗甲状腺球蛋白抗体(TG-Ab)、抗甲状腺过氧化物酶抗体(TPO-Ab)。结果围绝经期桥本氏甲状腺炎患者体内雌二醇水平为313.19±49.27pg/ml,对照组雌二醇水平为186.26±22.12pg/ml,两者相比差异有统计学意义。结论围绝经期桥本氏甲状腺炎患者体内雌二醇水平与对照组相比明显升高,差异具有统计学意义,由此推测在围绝经期女性桥本氏甲状腺炎患者的发病过程中雌激素可能起到了一定的作用。更多还原

【Abstract】 Objective Through the analysis of the change of estrogen in perimenopausal women who suffered with hashimoto’s thyroiditis,to explore the relationship between estrogen level and perimenopausal women Hashimoto’s thyroiditis.Methods Selected 40 cases of perimenopausal women who suffered with hashimoto’s thyroiditis and 40 healthy volunteers of perimenopausal women,in the fourteenth days of menstruation dettectted the Estradiol levels.The diagnosis of patients with Hashimoto bridges rely mainly on thyroid function three namely including FT3,FT4,TSH and the thyroid autoimmune antibodies including anti thyroglobulin antibody(TGAB)and anti thyroid peroxidase antibody(TPOAb).Results The average estradiol level in perimenopausal patients was 313.19±49.27pg/ml,the estradiol level in the control group was 186.26±22.12pg/ml,the difference between them was statistically significant.Conclusion The level of the estrogen in perimenopausal women who suffered with hashimoto’s thyroiditis compared with the control group is significantly increased,the difference between them was statistically significant.It can be inferred that the estrogen may play a role in the pathogenesis of perimenopausal women who suffered with hashimoto’s thyroiditis.更多还原