【摘要】 目的观察小剂量多巴酚丁胺早期干预治疗肺炎合并脓毒症的效果。方法 53例肺炎合并脓毒症患儿为研究对象,随机分为治疗组(26例)和对照组(27例),两组均于入院后2 h内给予静脉滴注抗生素,必要时给予静脉滴注丙种球蛋白(丙球)、甲泼尼龙(甲强龙)及呼吸机辅助通气等治疗;治疗组在上述治疗的同时加用小剂量多巴酚丁胺泵入[剂量2~5μg/(kg·min)],早期干预治疗,应用前先纠正低血容量。结果治疗组器官衰竭的发生率为15.38%(4/26),无死亡病例,平均住院时间(14.6±3.3)d,呼吸困难消失时间为(3.2±0.9)d,血压稳定时间为(4.5±0.9)d;对照组器官衰竭的发生率为48.15%(13/27),死亡4例(14.81%),平均住院时间(21.4±6.2)d,呼吸困难消失时间为(7.6±2.3)d,血压稳定时间为(8.8±1.9)d。两组器官衰竭发生率及病死率、住院时间、呼吸困难的消失时间、血压稳定时间比较,差异均有统计学意义(P<0.05)。结论小剂量多巴酚丁胺早期干预治疗肺炎合并脓毒症,可降低器官衰竭的发生率及病死率,缩短住院时间。值得同仁借鉴。更多还原

【Abstract】 Objective To observe effect of small dose dobutamine for early interventing treatment of pneumonia complicated with sepsis. Methods A total of 53 pneumonia complicated with sepsis children as study subjects were randomly divided into treatment group(26 cases) and control group(27 cases). Both groups received intravenous drip of antibiotics within 2 h after hospital admission, and intravenous drip of gamma globulin and methylprednisolone, respirator assisted ventilation were given if necessary. The treatment group also had small dose dobutamine [ dosage as 2~5 μg/(kg·min)] pumping for early intervention, and all this was done before correction of hypovolemia. Results The treatment group had incidence of organ failure as 15.38%(4/26), 0 dead case, mean hospital stay time as(14.6±3.3) d, breathing difficulties disappear time as(3.2±0.9)d, blood pressure stable time as(4.5±0.9)d, which were 48.15%(13/27), 4 cases(14.81%),(21.4±6.2)d,(7.6±2.3)d and(8.8±1.9)d in the control group. There were statistically significant difference in incidence of organ failure and mortality, hospital stay time, breathing difficulties disappear time, blood pressure stable time in two groups(P<0.05).Conclusion Small dose dobutamine for early interventing treatment of pneumonia complicated with sepsis can reduce incidence of organ failure and mortality, and short hospital stay time. It is worth referring.更多还原