【摘要】 目的研究氯胺酮在婴幼儿体外循环(CPB)手术中对炎性细胞因子的影响。方法 32例拟在CPB下行心内直视手术的先天性心脏病(先心病)婴幼儿,随机分为两组,每组16例。氯胺酮组(K组)转流前经中心静脉泵入氯胺酮1 mg/kg;对照组(C组)给予等量平衡液。分别于转流前和转流后从中心静脉采血检测血清肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-8和IL-10的浓度。结果 1与转流前相比,转流后C、K组TNF-α、IL-6、IL-8和IL-10含量均明显升高,差异均具有统计学意义(P<0.05);2组间比较,转流前两组TNF-α、IL-6、IL-8和IL-10含量变化不明显,转流后K组TNF-α、IL-6、IL-8含量明显低于C组,而IL-10含量显著高于C组,差异均具有统计学意义(P<0.05)。结论氯胺酮可抑制婴幼儿CPB手术中炎性细胞因子的产生,从而减轻缺血再灌注损伤。更多还原

【Abstract】 Objective To research influence by ketamine on inflammatory cytokines in infants cardiopulmonary bypass(CPB) operation. Methods A total of 32 infants with congenital heart disease, who received CPB-assisted open-heart surgery, were randomly divided into two groups, with 16 cases in each group. Ketamine group(group K) received ketamine by 1 mg/kg through central vein before bypass, and control group(group C) received equivalent equilibrium liquid. Central vein blood were taken before and after bypass to detect concentrations of tumor necrosis factor-α(TNF-α), interleukin(IL)-6, IL-8 and IL-10. Results 1 Comparing with those before bypass, both group C and group K had obviously higher contents of TNF-α, IL-6, IL-8 and IL-10 after bypass. Their differences all had statistical significance(P<0.05). 2 Before bypass, there was no obvious changes of contents of TNF-α, IL-6, IL-8 and IL-10 between the two groups. After bypass, group K had much lower contents of TNF-α, IL-6, IL-8 and higher IL-10 contents than group C. Their differences all had statistical significance(P<0.05). Conclusion Ketamine can reduce damage of ischemia reperfusion by suppressing occurrence of inflammatory cytokines in infants CPB operation.更多还原