【摘要】 目的探讨强迫症(obsessive-compulsive disorder,OCD)患者道德厌恶感特征,及其与患者强迫症状的关系。方法纳入28例OCD患者和30名性别、年龄、受教育年限与患者相匹配的正常对照,以词汇判断任务测试被试对道德厌恶词、核心厌恶词、中性词进行厌恶判断的反应时、正确率及厌恶程度评级,采用耶鲁布朗强迫量表(Yale-Brown obsessive-compulsive scale,Y-BOCS)、帕多瓦量表—华盛顿州立大学修订版(Padua inventory-Washington State University revision,PI-WSUR)评估患者强迫症状。结果 OCD组对核心厌恶词([762.69±128.25)ms vs(.648.69±162.66)ms]和道德厌恶词([798.73±115.26)ms vs(.727.00±106.06)ms]的反应时较对照组长,对核心厌恶词([6.38±1.78)vs(.5.03±1.64)]和道德厌恶词([7.08±1.23)vs(.5.77±1.44)]的厌恶程度亦高于对照组,且差异均有统计学意义(P<0.05)。OCD组对两类厌恶词的厌恶程度与Y-BOCS总分及Y-BOCS强迫思维分、强迫行为分、PI-WSUR总分及污染/清洗强迫因子、穿衣/打扮强迫因子、检查强迫因子、伤害他人/自己的强迫想法、伤害他人/自己的强迫冲动得分均呈正相关(P<0.05)。多因素线性回归分析示,只有污染/清洗强迫因子分别与核心厌恶词(β=0.61,P<0.01)和道德厌恶词(β=0.54,P<0.01)厌恶程度有关联。结论 OCD患者道德厌恶感及核心厌恶感均较对照组更强烈。道德厌恶感与强迫症状相关,受影响最大的是污染/强迫清洗症状。更多还原

【Abstract】 ObjectiveThis study aims to investigate the moral disgust cognitive processing of patients with obsessive-compulsive disorder(OCD) and its relationship with OCD symptoms.MethodsTwenty-eight OCD and 30 healthy controls matched for gender, age and education completed lexical decision task, recording reaction time and accuracy of words and assessing the degree of disgust. Yale-Brown obsessive-compulsive scale(Y-BOCS) and Padua Inventory-Washington State University Revision(PI-WUSR) were used to assess the symptoms.ResultsOCD group showed significantly longer reaction time to core disgust-related words [(762.69±128.25) ms vs.(648.69±162.66) ms] and moral disgust-related words [(798.73 ± 115.26) ms vs.(727.00 ± 106.06) ms] than the healthy controls(P<0.05). OCD group showed significantly higher aversion degree to core disgust-related words [(6.38±1.78) vs.(5.03±1.64)] and moral disgust-related words [(7.08±1.23) vs.(5.77±1.44)] than control group(P<0.05). Y-BOCS total score, Y-BOCS obsessive thoughts score, Y-BOCS compulsive behavior score, total score of PI-WUSR, cleaning/pollution force factor score, hurting themselves and others force factor were positively correlated with two types of disgust-related words in patients group(P<0.05). Multiple stepwise regression analysis between disgust words and Y-BOCS/PI-WUSR scores pointed that only CWCF influenced disgust degree of core disgust-related words(β=0.61, P<0.01) and moral disgust-related words(β=0.54, P<0.01), respectively.ConclusionThe core disgust and moral disgust of OCD are stronger compared to controls.更多还原