【摘要】 目的研究HBs Ag定量在慢性乙型肝炎患者干扰素抗病毒治疗期间的变化及临床意义。方法收集43例接受IFN-α治疗的HBe Ag阳性慢性乙型肝炎患者为研究对象。分别在治疗前和治疗后1、3和6个月时定量检测患者血清HBs Ag水平;并同时监测其HBV DNA、HBe Ag、HBc Ab及ALT的水平。结果 43例患者治疗前和治疗后1、3、6个月时血清HBs Ag水平呈下降趋势,差异具有统计学意义(P=0.029);治疗1个月时较治疗前有所下降,但差异无统计学意义(t=-1.12、P=0.304);治疗3个月和6个月时均较治疗前显著下降,差异具有统计学意义(t=-2.71、P=0.015,t=-2.71、P=0.010);其他不同时间点间比较差异均无统计学意义。IFN-α治疗6个月时患者血清HBs Ag下降>0.5 log10IU/ml组患者ALT复常率高于下降<0.5 log10IU/ml组,差异具有统计学意义(χ~2=5.536、P=0.019);下降>0.5 log10IU/ml组HBe Ag阴转率高于下降<0.5 log10IU/ml组,差异具有统计学意义(χ~2=4.226、P=0.040);下降>0.5 log10IU/ml组HBe Ag血清学转换率高于下降<0.5 log10IU/ml组,差异具有统计学意义(χ~2=4.226、P=0.040)。结论 HBs Ag定量在慢性乙型肝炎患者IFN-α治疗早期呈下降趋势。HBs Ag定量在慢性乙型肝炎IFN-α治疗早期下降迅速的患者ALT复常率、HBe Ag阴转率及HBe Ag血清学转换率均高于下降缓慢者。更多还原

【Abstract】 Objective To investigate the changes and clinical significance of quantitative hepatitis B surface antigen(HBs Ag) in patients with chronic hepatitis B(CHB) receiving interferon-α(IFN-α) therapy. Methods Total of 43 CHB patients with HBe Ag-positive who received IFN-α therapy were enrolled. The levels of serum HBs Ag were detected before treatment and after 1 month, 3 months and 6 months respectively; while the levels of HBV DNA, HBe Ag, HBc Ab and ALT were monitored, respectively. ResultsThe levels of serum HBs Ag decreased during the IFN-α therpy, with significant difference(P = 0.029); the level of HBs Ag at 1 month after treatment was lower than the baseline, but with no significant difference(t =-1.12, P = 0.304); the level of HBs Ag at 3 and 6 months after treatment were lower than the baseline, with significant differences(t =-2.71, P = 0.015; t =-2.71, P = 0.010); there were no significant difference between other time points(P all > 0.05). After 6 months treatment, the patients with a reduction of HBs Ag > 0.5 log10IU/ml achieved higher ALT normalization rate(χ~2 = 5.536, P = 0.019), HBe Ag loss rate(χ~2 = 4.226, P = 0.040) and HBe Ag seroconversion rate(χ~2 = 4.226, P = 0.040) than the rest patients with a reduction of HBs Ag < 0.5 log10IU/ml. Conclusions The levels of serum HBs Ag in patients with CHB decreased during IFN-α early treatment. The patients whose serum HBs Ag decreased faster had higher ALT normalization rates, HBe Ag loss rates and HBe Ag seroconversion rates than the other ones.更多还原