【摘要】 戊型肝炎病毒(hepatitis E virus,HEV)是发展中国家引起急性病毒肝炎的主要病原体。哺乳类动物的HEV有4个主要基因型,1型和2型只感染人,通过污染的水源引起暴发流行;3型和4型属于人畜共患病原体,常引起散发病例。近年来,基因3型引起的戊型肝炎(戊肝)慢性化现象受到了学者的广泛关注,特别是人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者重叠HEV感染是否较易引发戊肝慢性化,世界各地有许多相关研究,但结果不尽相同。因此,为进一步阐明HIV感染与HEV感染及转归的相关性,本文拟对近年来HIV感染群体的HEV流行情况、重叠HEV感染的相关风险因素与HIV感染者中戊肝慢性化特点进行综述。更多还原

【Abstract】 Hepatitis E virus(HEV)is one of the most important pathogens for acute viral hepatitis prevailing in developing countries.There are four major genotypes of mammalian HEV.Genotype 1and 2are restricted to human infection and mainly transmitted by contaminated water;whereas genotype 3and 4are zoonotic that cause sporadic cases which are common in developed countries.In recent years,much more attention has been paid to the chronicity of HEV infection of genotype 3,and there are a number of relevant studies on whether the human immunodeficiency virus superinfection with hepatitis E virus is a risk factor for chronic HEV infection.However the results differ across studies.In this review,we summarize recent progress in the research of HEV epidemiology,risk factors and the characteristics of chronic HEV infection in HIV-infected patients to explain whether HIV infection is one of the risk factors for the chronicity of HEV infection.更多还原