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人类免疫缺陷病毒感染者重叠感染戊型肝炎病毒的相关研究进展

Research progress on human immunodeficiency virus superinfection with hepatitis E virus

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【作者】 贺云野曾航王玲

【Author】 HE Yun-ye;ZENG Hang;WANG Ling;Department of Microbiology and Infectious Disease Center,School of Basic Medical Sciences,Peking University Health Science Center;

【机构】 北京大学医学部基础医学院病原生物学系和感染病中心

【摘要】 戊型肝炎病毒(hepatitis E virus,HEV)是发展中国家引起急性病毒肝炎的主要病原体。哺乳类动物的HEV有4个主要基因型,1型和2型只感染人,通过污染的水源引起暴发流行;3型和4型属于人畜共患病原体,常引起散发病例。近年来,基因3型引起的戊型肝炎(戊肝)慢性化现象受到了学者的广泛关注,特别是人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者重叠HEV感染是否较易引发戊肝慢性化,世界各地有许多相关研究,但结果不尽相同。因此,为进一步阐明HIV感染与HEV感染及转归的相关性,本文拟对近年来HIV感染群体的HEV流行情况、重叠HEV感染的相关风险因素与HIV感染者中戊肝慢性化特点进行综述。

【Abstract】 Hepatitis E virus(HEV)is one of the most important pathogens for acute viral hepatitis prevailing in developing countries.There are four major genotypes of mammalian HEV.Genotype 1and 2are restricted to human infection and mainly transmitted by contaminated water;whereas genotype 3and 4are zoonotic that cause sporadic cases which are common in developed countries.In recent years,much more attention has been paid to the chronicity of HEV infection of genotype 3,and there are a number of relevant studies on whether the human immunodeficiency virus superinfection with hepatitis E virus is a risk factor for chronic HEV infection.However the results differ across studies.In this review,we summarize recent progress in the research of HEV epidemiology,risk factors and the characteristics of chronic HEV infection in HIV-infected patients to explain whether HIV infection is one of the risk factors for the chronicity of HEV infection.

【基金】 国家自然科学基金资助项目(81271827);北京市自然科学基金资助项目(7162103)
  • 【文献出处】 中国病毒病杂志 ,Chinese Journal of Viral Diseases , 编辑部邮箱 ,2016年05期
  • 【分类号】R512.91;R512.6
  • 【被引频次】1
  • 【下载频次】107
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