【摘要】 目的:分析中日医院妇科及体检中心就诊女性高危型人乳头瘤病毒(HR-HPV)感染及亚型分布情况。方法:采用荧光PCR技术对2015年中日医院妇科门诊6288例和体检中心1772例就诊女性进行HPV分型检测。结果:妇科就诊女性HR-HPV阳性共1434例,单一亚型感染1086例,多重感染348例,单一亚型感染率较高的为HPV16、52、58型;体检中心就诊女性HR-HPV阳性共199例,单一亚型感染154例,多重感染45例,单一亚型感染率较高的为HR-HPV58、52、16型;妇科和体检人群在HR-HPV16、33、39型阳性率差异有统计学意义(P<0.05)。妇科就诊女性中60~88岁感染率最高(24.18%),其次为17~29岁;体检中心就诊女性中17~29岁感染率最高(15.19%),其次为50~59岁;以上差异均有统计学意义(P<0.05)。妇科多重感染率较高的亚型为HPV16、58、39和52型,17~29岁多重感染率最高;体检中心多重感染率较高的亚型为HPV39、16和52型,17~29岁多重感染率最高。结论:在妇科和体检中心就诊女性的HR-HPV感染阳性率、亚型及高发年龄段存在差异,该数据可为HPV感染的预防、治疗及疫苗研制提供流行病学依据。更多还原

【Abstract】 Objective:To compare the prevalent difference of high-risk human papilloma virus(HR-HPV)infection in women between gynecological outpatients department and a health check-up center in China-Japan Friendship Hospital.Methods:HR-HPV infection were tested in 6288 patients in the gynecological outpatient department and 1722 women in the health check-up center.Results:There were 1434 cases with HR-HPV positive among 6288 patients.Among the positive cases,there were 1086 cases with single subtype and 348 with multiple subtype virus infections.The main subtype of single virus infection were HR-HPV 16,52 and58.There were 154 cases with single subtype and 45 cases with multiple subtype of virus infections and subtype of HR-HPV 58,52 and 16 in 1772 health check-up women.There were significant difference of positive rate in HR-HPV 16,33 and 39 between gynecological outpatients and health check-up women(P<0.05).The vulnerable age groups in gynecological outpatients were 60~88 years old and 17~29 years old but they were17~29 years old and 50~59 years old in the health check-up women.There were significant differences in the prevalence of infection in different age groups(P<0.05).Among the multiple subtype infection cases,the main infection subtypes were HR-HPV16,58,39 and 52 in the outpatient department patients and HR-HPV 39,16 and 52 in the individuals during health check-up.Conclusion:The subtype and age-related prevalence of HR-HPV infection were significant different between patients from gynecological outpatient department and individuals from a health check-up center.更多还原