【摘要】 氨基肽酶N(Aminopeptidase N,APN)是一种锌离子依赖性膜结合II型的金属跨膜糖蛋白,其广泛存在于人和哺乳动物的多种组织细胞中。APN是多种冠状病毒的黏附性受体,参与冠状病毒的粘附与侵袭,与病毒感染密切相关。本文对多种冠状病毒(HCoV-229E、FCoV、CCoV、TGEV、PEDV)的APN受体的结构、功能、抑制剂等研究进展进行了总结,重点介绍了其作为人和猪冠状病毒功能受体的进展。本文为深入研究和应用冠状病毒APN受体提供参考。更多还原

【Abstract】 Aminopeptidase N(APN),a type II transmembrane glycoprotein that belongs to zinic-dependent membranebound metallopretease family,exists in many tissues of human and mammals as the binding-receptor of coronavirus.Participating in the coronavirus adhesion and invasion,aminopeptidase N is closely related to the coronavirus infection.In this essay,there is an overview of structure,function and inhibitors of aminopeptidase N that as functional receptor of HCoV-229 E,FCoV,CCoV,TGEV,PEDV.This paper mainly introduces the progress of aminopeptidase N as functional receptors of human and swine coronavirus,so as to provide a reference to further research and application of APN receptor.更多还原