【摘要】 目的:探讨开放性食物激发试验(OFC)在牛奶蛋白过敏(CMPA)诊治中的作用。方法:回顾性分析2014年3月至2015年3月于吉林大学第一医院小儿消化科就诊的55例疑似CMPA患儿,予以氨基酸奶粉喂养2~4周后行OFC,阳性者确诊为CMPA,并继续予以氨基酸奶喂养,3月后再次进行OFC,进而探讨OFC在牛奶蛋白过敏诊治中的应用价值。结果:55例疑诊为牛奶蛋白过敏的患儿行OFC,其中阳性者52例,阳性率94.55%。明确诊断CMPA的52例患儿经氨基酸配方奶喂养3个月后行第2次OFC,仍有9例患儿结果阳性,阳性率17.30%;该9例患儿继续予以氨基酸配方奶喂养3个月后行第3次OFC仍有2例患儿结果阳性,阳性率3.85%。结论:OFC对于牛奶蛋白过敏患儿的诊断及观察诱导牛奶蛋白免疫耐受具有重要的临床意义。更多还原

【Abstract】 Objective: To study the diagnostic and therapeutic value of open food challenge in children with cow’s milk protein allergy. Methods: It is a retrospective analysis of 55 children with suspected cow’s milk protein allergy( CMPA) who attended the clinic of the pediatric gastroenterology department,the First Hospital of Jilin University from March 2014 to March 2015. These children were fed by a mino acid based formulae( AAF) for 2- 4 weeks and then open food challenge( OFC) test was performed. Those children who tested positive,were diagnosed as having CMPA. They were then fed with AAF for further 3 months and OFC was performed again. Then discusse the diagnostic and therapeutic value of open food challenge in children with cow’s milk protein allergy. Results: Out of 55 CMPA suspected children,52 tested positive with OFC yielding a positive rate of 94. 55%. These 52 children were fed with AAF for further 3 months and then tested with OFC,9 children tested positive yielding a positive rate of 17. 30%. These 9 children were again fed with AAF for 3 months and then tested with OFC. This time 2 children tested positive yielding a positive rate of 3. 85%. Conclusion: Open food challenge teats are of great significance in the diagnosis of CMPA,and evaluation of tolerance to cow’s milk protein( CMP).更多还原