【摘要】 目的评价不同疗程新辅助化疗对早期巨块型宫颈癌患者的疗效差别。方法收集59例接受新辅助化疗的早期巨块型宫颈癌患者:16例行1个疗程新辅助化疗,43例行2个疗程新辅助化疗。对比两组之间化疗有效性、术中情况及术后病理特征的差异。数据采用t检验及χ~2检验进行统计分析。结果 16例接受1个疗程新辅助化疗的患者中有效者10例,有效率为62.5%;43例接受2个疗程新辅助化疗的患者中有效者41例,有效率为95.3%;2个疗程新辅助化疗的有效率更高(P=0.000)。两组患者的手术时间、术中出血量及术后并发症率分别为:(3.58±0.46)h和(3.55±1.06)h、(313.75±130.22)ml和(283.95±358.21)ml以及43.8%和69.8%,两组对比无统计学差异(P>0.05)。2个疗程新辅助化疗患者术后淋巴脉管间隙浸润率更低(7.0%及31.3%,P=0.046)。结论 2个疗程新辅助化疗较1个疗程新辅助化疗的有效率更高,可以降低淋巴脉管间隙浸润率,有利于控制微转移灶,建议宫颈癌新辅助化疗至少进行2个疗程。更多还原

【Abstract】 Objective To evaluate clinical efficacy of neoadjuvant chemotherapy with different courses on early stage bulky cervical carcinoma. Methods A total of 59 cases with early stage bulky cervical carcinoma were enrolled and divided into two groups according to different courses: 16 cases accepted 1 course of neoadjuvant chemotherapy and 43 cases accepted 2 courses. The effectiveness of neoadjuvant chemotherapy, blood loss during operation, surgical complications and pathological characteristics were compared between two groups. t test and χ~2 test were used to analyze data. Results The response rate of neoadjuvant chemotherapy with 2 courses was 95.3%(41 cases among 43 cases), which was higher than 1 course of 62.5%(10 cases among 16 cases)(P=0.000). No difference was found between two groups in operating time, blood loss during operation and operative complication rate(P>0.05):(3.58±0.46)h vs.(3.55±1.06) h,(313.75±130.22)ml vs.(283.95±358.21)ml and 43.8% vs. 69.8%. Compared to the other group, the rate of lymphatic vascular space invasion was lower in 2 courses group(7.0% vs. 31.3%, P=0.046). Conclusions The response rate of neoadjuvant chemotherapy with 2 courses was better than 1 course. 2 courses could reduce the rate of lymphatic vascular space invasion which could eliminate minute metastatic lesions. At least 2 courses of neoadjuvant chemotherapy were recommended for early stage bulky cervical carcinoma.更多还原