【摘要】 目的探讨弥散加权成像(DWI)在新生儿低血糖性脑病(HE)中的快速诊断价值。方法回顾性分析24例临床诊断符合新生儿HE的患者,均于出生后4~15 d内进行了头颅常规T1WI、T2WI、FLAIR和DWI扫描。比较患儿脑内T1WI、T2WI、FLAIR和DWI序列的表现。结果 24例新生儿HE中,顶枕叶受累22例(其中6例仅累及顶枕叶),胼胝体压部受累18例。病灶在DWI较T2WI信号高,且范围更清楚。DWI对新生儿HE病灶的显示率明显高于T1WI(χ2=59.733,P=0.000)、T2WI(χ2=36.771,P=0.000)和FLAIR(χ2=24.380,P=0.000)的显示率。结论新生儿HE在MRI上常表现为较特征的双侧顶枕叶和胼胝体压部受累,DWI有助于快速诊断急性期新生儿HE。更多还原

【Abstract】 Objective To explore the diagnose value of diffusion-weighted imaging(DWI) in neonatal hypoglycemic encephalopathy(HE). Methods Twenty-four patients with clinical proved neonatal HE were retrospectively analyzed. All patients received conventional MRI and DWI within 4-15 days after birth because of hypoglycemia. The appearances on T1 WI, T2 WI, FLAIR and DWI were recorded and compared. Results Twenty-two out of 24 showed occipital or parietal cortex involvement and 6 patients only showed occipital or parietal cortex abnormalities without other lesions, and the involvement sites were splenium of corpus callosum(n=18). Most of neonatal HE lesions showed clearer and higher signal intensity on DWI than on T2 WI. For displaying the lesions of neonatal HE, DWI was obviously superior to T1WI(χ2=59.733, P=0.000), T2WI(χ2=36.771, P=0.000) and FLAIR(χ2=24.380, P=0.000), respectively. Conclusions Neonatal HE often shows characteristic parieto-occipital regions and splenium of corpus callosum involvement on MRI, and DWI is helpful in the early diagnosis of neonatal HE.更多还原