【摘要】 目的探讨强迫症(OCD)患者不同区域脑组织代谢特点。方法选择17例首诊未经治疗的成人OCD患者为研究对象,并以性别、年龄、受教育程度匹配的17例健康志愿者为对照组,采用3D-多体素氢质子磁共振波谱分析OCD患者前扣带回、中扣带回、左右额叶白质、左右丘脑和左右豆状核中大脑代谢物N-乙酰门冬氨酸(NAA)、胆碱(Cho)和肌酸(Cr)浓度变化,并分析NAA/Cr、Cho/Cr与OCD、焦虑和抑郁量表评分的相关性。结果 OCD患者中扣带回的Cho/Cr明显低于对照组(P<0.05),左额叶白质Cho/Cr明显高于对照组(P<0.05);中扣带回NAA/Cr与焦虑量表评分呈正相关(r=0.712,P<0.05)。结论 OCD患者中扣带回Cho浓度减少、左额叶白质Cho浓度增高,可能是OCD的病理现象或代偿反应;中扣带回NAA/Cr与焦虑量表评分呈正相关。更多还原

【Abstract】 Objective To evaluate untreated adult patients with obsessive-compulsive disorder(OCD) with 3D multiple voxel 1H magnetic resonance spectroscopy(1H MRS).M ethods Seventeen untreated adult OCD patients and 17 age-and sex-matched healthy subjects were included in this study.The ratios of N-acetylaspartate(NAA) and choline(Cho) to creatine(Cr)in different brain regions were evaluated with 3D multiple voxel 1H MRS and compared between two groups.Results The Cho/Cr ratio in middle cingulated cortex of OCD patients was significantly lower than that of healthy controls(P<0.05).The Cho/Cr ratio in left frontal white matte of OCD patients was significantly higher than that of healthy controls(P <0.05).There was a positive correlation between anxiety symptoms and Cho/Cr ratio in the middle cingulated cortex of OCD patients(P<0.05).Conclusion There are decreased Cho level in middle cingulated cortex and increased Cho level in left frontal white matter in OCD patients,which may provide a newevidence for cortical-striatum-thalamus-cortical neuronal circuit theory.更多还原