【摘要】 目的探究糖尿病视网膜病变前期(NDR)视盘周围视网膜神经纤维层(RNFL)厚度的动态变化。方法选取NDR患者24例和健康对照者30例,用光学相干断层扫描仪测量两组视盘周围RNFL厚度,每间隔6个月复查1次,共检测5次;比较两组视盘全周及各象限RNFL厚度的动态变化。结果 NDR组与对照组视盘周围RNFL均值为(104.42±15.75)、(114.28±6.69)μm,NDR组视盘全周、上方、下方和颞侧象限RNFL厚度均小于对照组(P<0.05);NDR组每次测量(共5次)的视盘全周RNFL厚度均小于对照组(P<0.05)。上方与鼻侧、上方与颞侧、下方与鼻侧、下方与颞侧象限RNFL厚度两两比较,差异均有统计学意义(均P<0.05)。结论 NDR患者RNFL变薄,且随病程发展持续存在,以视盘上方、下方象限尤为显著。更多还原

【Abstract】 Objective To investigatethe dynamic changes of retinal nerve fiber layer(RNFL) thickness around disc in early stage diabetic retinopathy(EDR).Methods Twenty-four patients with early stage retinopathy and 30 healthy subjects underwent optical coherence tomography(OCT) examinations and the RNFL thickness around the optic disc was calculated.The OCT measurements were repeated with an interval of 6 months for 5 times.The dynamic changes of RNFL thickness were compared between two groups.Results The mean RNFL thickness around the optic disc of the control group was 114.28 ±6.69μm,whereas it was 104.42±15.75μm in NDR group.There were statistically significant differences in superior,inferior,temporal quadrant and peripapillary RNFL thickness between the control and EDR groups(P<0.05).The average RNFL thickness in EDR group was significantly thinner than that in control group at all five measurements(P<0.05).Compared with nasal and temporal quadrants,the RNFL thickness in superior and inferior quadrants was reduced more markedly in EDR group.Conclusion With the development of disease,the RNFL thickness of early stage diabetic retinopathy is gradually decreased,especially in superior and inferior quadrants.更多还原