【摘要】 TANK结合激酶1(TBK1)是Ⅰ型干扰素合成过程中最为关键的蛋白激酶,在抗病毒固有免疫应答中发挥重要的作用。TBK1可以被RIG-I-MAVS、cGAS-STING和TLR3/4-TRIF抗病毒信号通路所活化,作为重要的节点蛋白,其活化受到磷酸化、泛素化、SUMO化等一系列机制复杂而精密的调控。本文对TBK1在抗病毒免疫应答中的作用及其调控机制的研究进展进行综述。更多还原

【Abstract】 The innate immune response against viral infection is mainly relies on type I interferon,the production of which is mediated by TANK-binding kinase 1(TBKl).It is revealed that the downstream TBKl is activated by viral nucleic acid sensors RIG-I,cGAS and TLR3.The activity of TBKl is complexly and precisely regulated by different type of protein modifications,including phosphorylation,ubiquitination and Sumolylation.This article focuses on the role of TBKl in anti-viral innate immunity and the regulatory mechanism for the TBKl activation.更多还原