【摘要】 目的观察不同疗程1%国产卢立康唑乳膏对念珠菌性包皮龟头炎的治疗效果及安全性。方法采用随机方法将90例患者平均分成A、B、C 3组,分别给予卢立康唑1周治疗,2周治疗以及酮康唑乳膏2周对照治疗,用药后1、2、4周评价临床疗效、真菌学清除率以及不良反应。结果 90例入组患者中有86例患者进行疗效评价,治疗后1周时3组的有效率分别为69.0%、64.3%、65.5%(P>0.05),3组的真菌清除率分别为82.8%、82.1%、82.8%(P>0.05);治疗后2周时3组的有效率分别为72.4%、78.6%、75.9%(P>0.05),3组的真菌清除率分别为82.8%、85.7%、86.2%(P>0.05);治疗后4周时3组的有效率分别为75.9%、85.7%和82.8%(P>0.05),3组真菌清除率分别为86.2%、85.7%和89.7%(P>0.05),治疗后第1、2、4周3组之间疗效和真菌清除率均无显著性差异(P>0.05)。不良事件发生率低(2.3%),仅为局部不良反应。结论 1%卢立康唑乳膏治疗念珠菌性包皮龟头炎安全有效,1周疗程与2周疗程疗效相当。更多还原

【Abstract】 Objective To investigate the efficacy and safety of different course of domestic luliconazole 1% cream in the treatment of candidal balanoposthitis.Methods Ninty patients were divided randomly and equally into 3groups:A group applying luliconazole 1% cream once daily for 1week;B group applying luliconazole 1% cream once daily for 2weeks;C group applying ketoconazole 2% cream twice daily for 2weeks.Efficacy,rates of mycological clearance and adverse reactions were assessed on week 1,2,4after treatment.Result A total of 90 patients were enrolled and 86 patients were evaluated for efficacy.The clinical response rates in the three group were 69.0%,64.3% and 65.5% respectively(P>0.05),the rates of mycological clearance were 82.8%,85.7% and 86.2% respectively on week 1after initiation of treatment(P>0.05).The clinical response rates in the three group were 72.4%,78.6%and 75.9%respectively;the rates of mycological clearance were 82.8%,85.7% and 86.2% respectively on week 2after initiation of treatment(P >0.05).The clinical response rates in the three group were 75.9%,85.7% and 82.8%respectively;the rates of mycological clearance were 86.2%,85.7% and 89.7%respectively on week 4after initiation of treatment(P>0.05).There were not significant differences in the efficacy and the rates of mycological clearance between three groups on week 1,2,4after treatment.The incidence of adverse events was very low.All of the adverse events were mild local adverse events.Conclusion Domestic luliconazole 1%cream can be used effectively and safely in the treatment of candidal balanoposthitis,with the efficacy of 1-week regimen equivalent to that of 2-week regimen.更多还原