【摘要】 雌激素作为一种由卵巢、胎盘和肾上腺皮质分泌产生的激素在维持女性正常功能和骨代谢平衡中起着重要作用。近年来的研究逐渐表明,人雌激素受体能在软骨细胞中表达且雌激素受体(estrogen receptor,ESR)基因多态性与骨性关节炎(osteoarthritis,OA)的发病密切相关。同时,对OA患者行雌激素或选择性雌激素受体调节剂(selective estrogen receptor modulators,SERMS)治疗能在一定程度上起到保护性作用。本文从分子生物学和临床分析的角度就雌激素及其受体与OA的具体相关性进行深入探讨,以更好的为OA的预防和治疗提供新的理论依据。更多还原

【Abstract】 Estrogen is a kind of hormone secreted by the ovaries,placenta,and adrenal and plays an important role in maintaining the normal function of women and bone homeostasis.Recent studies increasingly suggest that human estrogen receptor(ESR) can be expressed in chondrocytes and ESR gene polymorphisms are closely associated with the onset of osteoarthritis(OA).Also,estrogen or selective estrogen receptor modulators(SERMS) therapies on patients with OA may exert protective effects in a certain extent.From the perspective of molecular biology and clinical analysis,this review made a in-depth analysis on the specific association between estrogen and its receptors and OA to provide a new theoretical basis for the prevention and treatment of OA.更多还原