Study on the clinical relationship between the biochemical indicators in cerebrospinal fluid and cognitive function in patients with epileptic cerebral cysticercosis and patients without epileptic cerebral cysticercosis
目的检测癫痫型与非癫痫型脑囊虫病患者脑脊液生化指标,探讨生化指标与认知功能的关系,为脑囊虫病的临床诊治提供依据。方法选取2005年1月至2015年12月间在本院诊治的38例癫痫型脑囊虫病患者和49例非癫痫型脑囊虫病患者,检测两组患者脑脊液中谷氨酸(glutamate,GLU),天冬氨酸(aspartame acid,ASP),γ-氨基丁酸(γ-amino butyric acid,GABA)、甘氨酸(glycine,GLY)、亮氨酸脑啡肽(leu-enkephalin,L-ENK)、以及一氧化氮(nitric oxide,NO)的含量,并采用简易智能精神状态检查量表(mini-mental state examination,MMSE)测评两组的认知功能,分析生化指标对认知功能的影响。结果癫痫型脑囊虫病患者脑脊液中GLU、L-ENK、GABA、NO含量分别为(404.62±21.38)pmol/ml、(498.53±216.42)ng/L、(134.59±12.46)pmol/ml、(25.16±3.82)μmol/L和(16.43±5.38)pmol/ml,非癫痫型脑囊虫病患者分别为(383.53±23.1...
【英文摘要】
Objective To measure biochemical indicators in the cerebrospinal fluid(CSF)in order to explore the relationship between levels of biochemical indicators in the CSF and cognitive function in patients with epileptic cerebral cysticercosis and patients without epileptic cerebral cysticercosis in order to facilitate the clinical diagnosis and treatment of cerebral cysticercosis. Methods Subjects were 38 patients with epileptic cerebral cysticercosis and 49 patients without epileptic cerebral cysticercosis who w...