The tablet cores loaded with paliperidone were prepared with wet granulation, then coated with a sustained-release layer to obtain the title tablets. The matrix materials and p H modifiers of the tablet cores, formulation composition and weight gain of sustained-release coating layer were optimized with the release similarity between the self-made tablets and the reference listed drug(RLD) product(Invega~?) as the index. The results showed that the optimal formulation was as follows: the matrix materials of...
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