Objective To investigate the effect of targeting inhibition of PI3 K on the regulation of p38 /c-Fos signaling pathway in osteoclast differentiation. Methods Mononuclear cells were isolated from human peripheral blood and were induced to osteoclasts.Cells in the treatment group were treated with PI3 K targeting inhibitor LY294002. Cell morphology was observed and cell proliferation was measured. The p38 MAPK pathway and the gene and protein expression level of transcription factor c-fos were detected using ...
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