【摘要】 生理情况下原癌基因信号传导及转录激活子3(signal transducer and activator of transcription-3,STAT3)的激活受到严格的调控。然而,大量证据表明,STAT3在许多肿瘤细胞中存在持续激活,并在肿瘤的起始与进展中发挥重要作用。目前的研究发现,活化的STAT3能够通过多种方式促进肿瘤的进展,如促进肿瘤细胞的增殖、侵袭转移、耐药、上皮-间质转化、调节肿瘤微环境、促进肿瘤干细胞的更新与分化等。STAT3的激活除了受传统的细胞因子和生长因子信号通路的调控以外,大量的证据显示G-蛋白偶联受体、钙黏素、Toll样受体、miRNA以及乙酰化修饰等也在STAT3活化过程中发挥了重要作用。本文主要针对肿瘤细胞中调控STAT3活化的途径进行综述。更多还原

【Abstract】 The activation of the proto-oncogene STAT3 is strongly controlled under physiological conditions.However,obtained evidence revealed that STAT3 is persistently activated in cancer cells and contributes to cancer initiation and progression.Studies demonstrated the various functions of activated STAT3 in promoting cancer development and aggravation,including cancer cell proliferation,invasion and metastasis,drug resistance,epithelial-mesenchymal transition,regulation of the tumor microenvironment,and promotion of the self-renewal and differentiation of cancer stem cells.Canonically,STAT3 is regulated by signaling pathways mediated by cytokines and growth factors.Many studies determined that STAT3 was also regulated by G protein-coupled receptors,cadherin engagement,Toll-like receptors,micro RNA,and acetylation.We summarized the recent developments in the research on the regulation of STAT3 activation.更多还原