【摘要】 目的研究重症患者多次用比阿培南后群体药动学。方法入组重症患者接受比阿培南300 mg多次静脉滴注后按不同时间点采血,应用建立的高效液相色谱法测定血药浓度,计算药动学参数。结果受试重症患者主要药动参数ρ_max,T_max,AUC₉0-∞),T_1/2,CL,Vd分别为（6.66±2.93）mg·L^-1,（0.51±0.04）h,（18.98±16.95）mg·h·L^-1,（2.06±1.93）h,（20.9±17.4）L·h-1,（46.43±3.5）L,与文献报道健康人群的药动学数据差异显著。结论比阿培南在重症患者体内的药动学与健康人群有显著差异,需根据患者的药动学特征来制定个性化的抗感染方案。更多还原

【Abstract】 OBJECTIVE To research population pharmacokinetics of biapenem in critical patients after repeated dosing. METHODS Blood samples were collected according to the different time points after intravenous administration of 300 mg for many times in the group of critical patients. High-performance liquid chromatography（ HPLC） was used to determine the drug concentration in plasma. And pharmacokinetic parameters was caculated. RESULTS The main pharmacokinetic parameters for critical patients were as follows: ρ_max was（ 6. 66 ± 2. 93） mg·L^-1,T_max was（ 0. 51 ± 0. 04） h,AUC_0-∞ was（ 18. 98 ± 16. 95） mg·h·L^-1,T_{1 /2} was（ 2. 06 ±1. 93） h,Cl was（ 20. 9 ± 17. 4） L·h^{- 1},Vd was（ 46. 43 ± 3. 5） L. CONCLUSION The pharmacokinetic parameters of biapenem in critical patients with a significant difference was found in healthy people. So need according to pharmacokinetic characteristics of patients to develop personalized anti-infection plan.更多还原