【摘要】 目的 探讨环瓜氨酸肽（CCP）抗体及CD₄⁺CD₂₅⁺调节性T细胞（Treg细胞）水平与类风湿关节炎（RA）骨关节侵蚀之间的关系。方法 选取2014年1月至2015年1月成郜医学院第一附属医院收治的120例RA患者作为观察组,选取同时期自愿参与研究的40名健康人作为对照组,测定2组的CCP抗体及CD₅⁺CD₂₅⁺Treg细胞表达水平,并采用X线片评价骨关节侵蚀程度 结果 观察组CCP抗体阳性率明显高于对照组,差异有统计学意义[66.7%（80/120）比0.0%（0/40）,x²=17.78,P<0.01];CD₄⁺CD₂₅⁺Treg细胞水平明显低于对照组,差异有统计学意义[（3.4±1.8）%比（4.2±2.1）%,t=2.46,P<0.05]CCP抗体诊断RA的敏感度为66.7%,特异度100.0%。CCP阳性组（80例）骨关节侵蚀评分及骨关节侵蚀率明显高于CCP阴性组（40例）,差异有统计学意义[（7.9±3.4）分比（3.4±2.3）分、72.5%（58/80）比17.5%（7/40）,P<0.05]。CCP抗体与骨关节侵蚀率呈高度正相关（r=0.85,P<0.01）;CD₄⁺CD₂₅⁺Treg细胞水平与骨关节侵蚀率无相关性（r=-0.13,P>0.05）。结论 CCP抗体与RA患者骨关节侵蚀率呈正相关,但CD₄⁺CD₂₅⁺Treg细胞水平与骨关节侵蚀率无关。CCP抗体诊断RA敏感度和特异度较好,可作为临床RA早期诊断和预测骨关节侵蚀程度的指标。更多还原

【Abstract】 Objective To investigate the correlations between articular erosion with cyclic citrullinated peptide（CCP） antibody levels and associated egulatory T cells（Treg cells） in patients with rheumatoid arthritis（RA）.Methods Totally 120 RA patients（observation group） and 40 healthy people（control group） from January 2014 to January 2015 were enrolled.The levels of CCP antibody and CD₄⁺ CD₂₅⁺ Treg cells were measured and the degree of bone erosion were evaluated by X-ray.Results The positive rate of CCP antibody in observation group was significantly higher than that in observation group[66.7%（80/120） vs 0.0%（0/40）]（x² = 17.78,P <0.01）;the level of CD₄⁺ CD₂₅⁺ Treg cells in observation group was significantly lower than that in control group[（3.4 ± 1.8）%vs（4.2 ± 2.1）%]（t = 2.46,P < 0.05）.The sensitivity and specificity of CCP antibody in diagnosing RA was 66.7%and 100.0%.The articular erosion score and rate of articular erosion in patients with positive CCP（80 cases） were significantly higher than those in patients with negative CCP（40 cases）[（7.9 ±3.4） scores vs（3.4±2.3） scores,72.5%（58/80） vs 17.5%（7/40）]（P<0.05）.Level of CCP antibody was positively coirelated with articular erosion（r = 0.85,P < 0.01）;the level of CD₄⁺ CD₂₅⁺ Treg cells was not significantly coirelated with articular erosion（r =- 0.13,P > 0.05）.Conclusion Articular erosion is positively correlated with CCP antibody level,but not with the level of CD₄⁺ CD₂₅⁺ Treg cells in RA patients;the sensitivity and specificity of CCP antibody is good in diagnosing RA,and can be used as a predictive indicator of articular erosion degree.更多还原