【摘要】 目的探讨嘉兴市常见恶性肿瘤的危险因素,为进行全市肿瘤预防控制提供依据。方法收集肺癌、胃癌、肝癌、大肠癌(结、直肠癌)、食管癌、乳腺癌等6种常见原发恶性肿瘤600例,采用1∶2配对的病例对照研究,采用单因素及多因素logistic回归模型进行拟合,筛选嘉兴市常见恶性肿瘤的主要危险因素。结果做饭时眼睛或咽喉感觉受到烟雾刺激(OR=1.37)、十年前居住地500m内周围有工厂(OR=1.82)、被动吸烟(OR=1.24)、肺结核病史(OR=3.04)、血吸虫病史(OR=3.33)、肝病和肝硬化病史(OR=5.12)、其他下消化系疾病病史(OR=16.80)和直系亲属肿瘤史(OR=1.53)为恶性肿瘤发病的危险因素,自我调节强,易适应环境(OR=0.52)、近些年无较大的精神创伤(OR=0.63)为保护因素。结论做饭时眼睛或咽喉感觉受到烟雾刺激、十年前居住地500m内周围有工厂、被动吸烟、肺结核病史、血吸虫病史、肝病和肝硬化病史、其他下消化系疾病病史和直系亲属肿瘤史为嘉兴市常见恶性肿瘤发病的共同危险因素,自我调节强易适应环境、近些年无较大的精神创伤为保护因素。更多还原

【Abstract】 Objective To explore the risk factor of common malignant tumors in Jiaxing. Methods 600 cases with lung cancer,gastric cancer,liver cancer,colorectal cancer(junction,colorectal cancer),esophageal cancer,breast cancer and 1 200 matched controls were enrolled into our study.Single factor and multivariate logistic regression models were used for the risk factor analysis. Results Logistic regression analysis revealed that smoking irritation while cooking(OR=1.37),factories around the living area within 500 meters ten years ago(OR=1.82),passive smoking history(OR=1.24),tuberculosis(OR=3.04),history of schistosomiasis japonica infection(OR=3.33),liver disease and cirrhosis of the liver(OR=5.12),and other digestive disease history(OR=16.80)and family history of cancer(OR=1.53)were risk factors for malignant tumours,while,strong self-adjustment to adapt to the environment(OR=0.52),no large trauma in recent years(OR=0.63)were protective factors. Conclusions There are a lot of factors related to cancer,including environmental factors and disease history as well as family cancer history.更多还原