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我院433例药品不良反应报告分析

Analysis of 433 ADR Reports in Our Hospital

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【作者】 余文浩李玉珍曾繁涛刘君波陈旎旎徐小英

【Author】 YU Wenhao;LI Yuzhen;ZENG Fantao;LIU Junbo;CHEN Nini;XU Xiaoying;Dept.of Pharmacy,Shenzhen Futian District People’s Hospital;

【机构】 深圳市福田区人民医院药学部

【摘要】 目的:探讨我院药品不良反应(ADR)发生的临床特点、规律,为临床合理、安全用药提供参考。方法:对广东省ADR监测中心收录的我院2014年1月-2015年6月的ADR报告进行整理、统计与分析。结果:433例发生ADR的患者中,男性185例(42.73%),女性248例(57.27%),男女比例为1∶1.34。中青年(20~59岁)患者ADR发生率较高(71.59%),且男性明显少于女性(1∶1.37)。ADR给药途径以静脉滴注(48.04%)和口服给药(41.57%)为主。抗感染药物引发ADR的例数最多(167例,38.57%),其中以头孢菌素类为主(64.07%)。ADR累及器官/系统以消化系统损害(262例次,36.19%)和皮肤及其附件损害(237例次,32.73%)为主。严重的ADR主要涉及抗感染药物和抗肿瘤药物。结论:临床医务人员应加强头孢菌素类抗菌药物和抗肿瘤药物的ADR监测,谨慎选择给药途径。

【Abstract】 OBJECTIVE:To investigate the clinical characteristics and regularity of adverse drug reaction(ADR),and to provide reference for rational and safe drug use in the clinic. METHODS:ADR reports collected from our hospital by Guangdong ADR Monitoring Center during Jan. 2014 to June. 2015 were summarized and analyzed statistically. RESULTS:Of 433 ADR cases,there were 185 male cases(42.73%)and 248 female cases(57.27%),with ratio of 1∶1.34. The incidence of ADR was in high level(71.59%)in young and middle-aged patients(20-59 year-old);that of male was significantly lower than that of female(1∶1.37).ADR cases caused by intravenous drip(48.04%)and oral administration(41.57%)were most common. The most ADR cases were related with anti-infective drugs(167 cases,38.57%),mainly were related with cephalosporins(64.07%). Organs/systems involved in ADR were main the damages of gastrointestinal system(262 cases,36.19%) and the lesion of skin and appendants(237 cases,32.73%). The serious ADR was mainly induced by anti-infective and anti-tumor drugs. CONCLUSIONS:Clinical medical personnel should strengthen the ADR monitoring of cephalosporin antibiotics and anti-tumor drug,and select route of administration carefully.

【关键词】 药品不良反应分析合理用药
【Key words】 Adverse drug reactionAnalysisRational drug use
  • 【分类号】R954
  • 【被引频次】28
  • 【下载频次】168
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