【摘要】 目的:探讨血清免疫球蛋白E(IgE)水平与钙化性主动脉瓣疾病(CAVD)的关系。方法:符合入选标准的394例患者根据超声心动图结果分为CAVD组(n=169)和非CAVD组(non-CAVD组,n=225)。采用化学发光法测定血清IgE水平,分析两组患者间血清IgE水平的差异以及血清IgE水平与CAVD之间的关系。结果:CAVD组患者血清IgE水平显著高于non-CAVD组(113.30 IU/ml vs 63.76 IU/ml,P<0.05),多因素Logistic回归分析也提示两组间血清IgE水平的差异有统计学意义(P<0.05),且血清IgE水平与CAVD显著相关。结论:CAVD组患者血清IgE水平显著增高;血清IgE水平是提示CAVD的独立生化指标,IgE可能在CAVD的发病过程中起重要作用。更多还原

【Abstract】 Objective: To explore the relationship between serum levels of immunoglobulin E(IgE) and calcific aortic valve disease(CAVD) in relevant patients. Methods: A total of 394 patients were enrolled in our study. Based on echocardiography presentation, the patients were divided into 2 groups: CAVD group, n =169 and Non-CAVD group, n =225. Serum levels of Ig E were examined by chemiluminescence method. The IgE levels were compared between 2 groups and the relationship between serum IgE level and CAVD was analyzed.Results: Serum levels of Ig E in CAVD group was significantly higher than Non-CAVD group 113.30 IU/ml vs 63.76 IU/ml(P<0.05); multivariate logistic regression analysis confirmed above difference(P<0.05) and it also indicated that the alteration of surum IgE level is obviously related to CAVD occurrence.Conclusion: Serum IgE level is obviously increased in CAVD patients. IgE is an independent biochemical indicator of CAVD, it may play the important role in CAVD pathogenesis.更多还原