【摘要】 5-羟色胺(5-HT)是参与调节胃肠道运动、内脏敏感性、分泌等功能的重要神经递质和信号分子。肠道菌群对5-HT的产生有重要影响,已发现一些产芽孢细菌(spore-forming bacteria,SP)类肠道微生物能刺激肠嗜铬细胞(enterochromaffin cell,EC)产生5-HT。微生物通过Toll样受体(Toll-like receptors,TLR)激活神经分泌机制来调节胃肠运动,某些TLR通过作用于5-HT受体调节小鼠回肠的自主收缩和5-HT诱导的收缩反应。通过调节肠道菌群可以对5-HT综合征及其相关生理和病理状况产生重要影响。因此,对5-HT与TLR及肠道菌群相互之间的关系进行进一步的研究有重要意义。更多还原

【Abstract】 5-hydroxytryptamine(5-HT)is an important neurotransmitter and signaling molecule which involved in regulating gastrointestinal movement,visceral sensitivity and secretion function.Recent study have found some spore-forming bacteria(SP)gut microbes can stimulate the enterochromaffin cell(EC)to produce 5-HT.Microorganisms regulate gastrointestinal movement through Toll-like receptor(TLR)activated neurosecretory mechanism.Some TLRs can act on 5-HT receptor to regulate autonomic contraction in mice.The intestinal microbiota likely has important influence on 5-HT syndrome and is related with physiological and pathological conditions.Therefore,further research about the relationship among 5-HT,TLR and intestinal microbiota is valuable.更多还原