【摘要】 目的探讨七氟醚吸入麻醉与丙泊酚静脉麻醉对老年患者围术期的心肌保护作用。方法选择2014年3月~2015年3月于我院行食管癌根治术的老年患者40例,按随机数字表法将其分为七氟醚吸入麻醉组(S组)和丙泊酚静脉麻醉组(P组),每组20例,比较两组患者不同时间点的血清心肌肌钙蛋I(c Tn I)、micro RNA-499、micro RNA-208b水平。结果 1P组T2、T3、T4时刻的c Tn I含量均高于S组,差异有统计学意义(P<0.05);2P组T3时刻的micro RNA-499和micro RNA-208b含量均高于S组,差异有统计学意义(P<0.05)。结论七氟醚吸入麻醉较丙泊酚静脉麻醉更具心肌保护作用,对减少老年患者围术期心脏并发症有重要的意义。更多还原

【Abstract】 Objective To investigate the myocardial protective effect of sevoflurane inhalation anesthesia on perioperative period of elderly patients with propofol intravenous anesthesia. Methods 40 elderly patients who were given radical surgery for esophageal cancer in our hospital from March 2014 to March 2015 were selected.They were assigned to the group of inhalation anesthesia with sevoflurane(group S) and the group of intravenous anesthesia with propofol(group P)according to the random number table,with 20 patients in each group.The c Tn I level and micro RNA-499 and micro RNA-208 b levels at different time points were compared between the two groups of patients. Results 1 The contents of c Tn I in group P at the T2,T3,T4 was higher than that in group S respectively,and the differences was statistically significant(P<0.05).2The contents of micro RNA-499 and micro RNA-208 b at the T3 in group P was higher than that in group S respectively,and the differences was statistically significant(P <0.05). Conclusion Inhalation anesthesia with sevoflurane has better myocardial protection effects than intravenous anesthesia with propofol,and it has great significance in reducing the cardiac complications in elderly patients during the perioperative period.更多还原