【摘要】 目的分析慢性乙型肝炎病毒(HBV)感染孕妇不同HBe Ag血清学状态对不良妊娠结局的影响。方法回顾性调查2010年1月1日至2015年12月31日于南方医科大学南方医院分娩的440例HBs Ag(+)孕妇,将其分为HBe Ag(+)265例,HBe Ag(-)175例,随机选取同时期非HBV感染健康孕妇304例作对照组,分析各组不良妊娠结局的差异。另将378例HBV携带孕妇按HBV DNA是否≥1.0×10~6U/L,分为HBV DNA(+)174例及HBV DNA(-)204例,进一步比较两组不良妊娠结局的差异。结果 HBe Ag(+)组比非HBV感染健康孕妇组早产或胎膜早破发生风险更高,HBe Ag(-)组与非HBV感染健康孕妇组不良妊娠结局发生风险没有显著差异;HBV DNA(+)组早产、胎膜早破发生率分别为10.92%、13.22%,HBV DNA(-)组为3.43%、6.37%(P=0.004,P=0.024)。结论 HBe Ag(+)孕妇发生早产或胎膜早破风险高于HBe Ag(-)孕妇,HBe Ag(+)可作为预测早产或胎膜早破发生风险的高危因素。更多还原

【Abstract】 Objective To analyze the incidence of adverse pregnancy outcomes among pregnant women with different serum HBV antigen status.Methods The retrospective cohort study population comprised pregnant women who were admitted to Nanfang Hospital,Southern Medical University,Guangdong,China for delivery from January 1,2010 to December 31,2015.According to e-antigen status,440 cases of positive HBs Ag were divided into HBe Ag(+) group(265cases) and HBe Ag(-) group(175 cases).A total of 304 cases without chronic hepatitis B in pregnancy were included as control group.The difference in the adverse pregnancy outcome was analyzed among the groups.According to HBV DNA≥1.0×10~6U/L,378 cases were divided into HBV DNA(+) group(174 cases) and HBV DNA(-) group(204 cases).Differences between groups were compared.Results HBe Ag(+) groups had significant increased u ORs and a ORs regarding preterm birth and premature rupture of membrane when compared to the controls.There was no difference between HBe Ag(-) group and the control group.The incidence of preterm birth or preterm rupture of membranes in the HBV DNA(+) group were 10.92% and 13.22%,higher than the 3.43% and 6.37% of the HBV DNA(-) group(P=0.004,P=0.024).Conclusion Pregnant women with HBe Ag(+) are at higher risks of preterm birth or premature rupture of membrane.So HBe Ag status may be a simple marker for clinical implication as a risk predictor of preterm birth or premature rupture of membrane.更多还原