【摘要】 目的探讨瘤周谷氨酸、天门冬氨酸浓度与胶质瘤继发性癫痫的相关性。方法收集2012年5月2015年1月手术治疗的胶质瘤瘤周组织标本47例,其中继发癫痫28例(癫痫组),未继发癫痫19例(无癫痫组)。利用全自动L-8900高速氨基酸分析仪检测标本的谷氨酸、天门冬氨酸水平。结果癫痫组瘤周谷氨酸、天冬氨酸含量分别为(117.54±8.63)mg/100 g、(70.79±4.70)mg/100 g,均明显高于无癫痫组[分别为(91.76±7.36)mg/100 g、(59.70±5.50)mg/100 g;P<0.05]。瘤周谷氨酸、天冬氨酸含量与癫痫均具有显著相关性,相关系数分别为0.96、0.95(P<0.05)。结论瘤周组织谷氨酸、天门冬氨酸浓度增加可能与胶质瘤继发性癫痫有关。更多还原

【Abstract】 Objective To study the relationship of the levels of glutamate and aspartate in the peritumorous tissues with seizuresin order to provide the basis for understanding of pathophysiological mechanism of the epilepsy secondary to glioma.MethodsOf 47 specimens of gliomas, 28 were derived from the gliomas patients with secondary epilepsy and 19 from the gliomas patients withoutsecondary epilepsy. The levels of glutamate and aspartate in the peritumorous tissues were determined by automatic high-speed L-8900 amino acid analyzer.Results The levels of glutamate and aspartate in the peritumorous tissues were significantly higher in the gliomaspatients with secondary epilepsy than those in the gliomas patients without secondary epilepsy(P<0.05). The seizure with the levels ofglutamate and aspartate in the peritumorous tissues is positively correlated in the patients with gliomas.ConclusionIt is suggested thatthe higher concentrations of glutamate and aspartate in the peritumorous tissues may be one of the pathophysiological mechanisms ofseizures in the gliomas patients with secondary epilepsy.更多还原