【摘要】 通常鸡群通过垂直传播感染ALV-J后的致病性比通过水平传播更为严重。本研究通过对SPF鸡胚卵黄囊接种模拟了ALV-J经垂直传播感染鸡群后的致病性,在此基础上通过联合使用逆转录酶抑制剂类药物Zidovudine(AZT)和Lamivudine(LAM)并观察其对减缓ALV-J垂直传播致病性方面的作用。结果显示未使用药物的病毒感染组其体重、死亡率以及免疫ND和AI-H9灭活疫苗所产生的抗体水平均显著低于使用药物的病毒感染组(P<0.05),更显著低于未接毒的生理盐水对照组(P<0.05)。研究表明AZT和LAM等逆转录酶抑制剂类药物的使用有助于降低ALV-J垂直传播感染对鸡群的危害。更多还原

【Abstract】 The pathogenicity of chickens infected with ALV-J by vertical transmission was more severe than that by horizontal transmission. In this present study,we have simulated pathogenicity of the vertical transmission on chickens was inoculated with ALV-J by SPF embryos via yolk sac. We have observed the effect of nuclear reverse transcriptase inhibitors(NRTI)on the pathogenesis of ALV-J. The results showed that the index with body weight,mortality,and antibody levels of NDV and AIV-H9 were significantly lower than those of the NRTI in the infected group than without NRTI treatment group(P<0.05),and more significantly difference with control group(P<0.05). The results demonstrated that that AZT and LAM could be helpful to reduce the risk of vertical transmission of ALV-J on chickens.更多还原