【摘要】 目的了解上海市医务人员(Healthcare Workers,HCWs)麻疹、风疹及流行性腮腺炎(流腮)的抗体水平,为制定针对性的免疫策略提供依据。方法采集全市4家一级医院、3家二级医院、2家三级医院的HCWs的全血标本700份,检测血清麻疹、风疹及流腮Ig G抗体。结果 HCWs麻疹抗体阳性率为97.00%,几何平均浓度(Geometric Mean Concentration,GMC)为946.82 mIU/ml,不同年龄组、户籍类型、医院级别、科室类型、免疫史、患病史HCWs间麻疹抗体阳性率无统计学差异。风疹抗体阳性率为81.29%,GMC为39.16 IU/ml。流腮抗体阳性率为83.43%,GMC为225.03 IU/ml。Logistic回归结果显示,20~39岁HCWs风疹抗体阳性率高于40岁及以上HCWs;一级医院HCWs风疹抗体阳性率高于二、三级医院HCWs。50岁及以上HCWs流腮抗体水平高于20~49岁HCWs;一、二级医院HCWs流腮抗体水平高于三级医院HCWs。结论 HCWs对麻疹普遍免疫,但对既往无明确免疫史的HCWs,尤其是新进职工、护工、医学院研究生等对象开展含麻疹成分疫苗查漏补种仍有必要。同时加强对二、三级医院HCWs的宣传动员,进一步提高接种率,通过接种麻疹风疹或麻腮风联合减毒活疫苗控制HCWs中风疹和流腮的发病。更多还原

【Abstract】 Objective To evaluate the seroprevalences of measles,rubella and mumps among healthcare workers(HCWs) in Shanghai and to modify the immunization strategy for HCWs.Methods 700 blood samples from HCWs were collected from 4 primary hospitals,3 secondary hospitals and 2 tertiary hospitals.Ig G antibodies against measles,rubella and mumps were tested.Results The positive rate of Ig G antibody against measles was 97.00%,and the geometric mean concentration(GMC) was 946.82 mIU /ml;there were no significant differences among age groups,registered residences,department types,immunization history or infection history.The positive rates of Ig G antibodies against rubella and mumps were 81.29% and 83.43%,respectively,and the GMCs were 39.16 IU / ml and 225.03 IU / ml,respectively.Logistic analysis showed that the positive rate of antibody against rubella among HCWs aged 20-39 years was higher than among HCWs over 40 years old,and it was higher among HCWs from primary hospitals than among HCWs from secondary or tertiary hospitals.The positive rate of antibody against mumps among HCWs aged over 50 years was higher than among HCWs aged 20-49 years,and it was higher among HCWs from primary or secondary hospitals than among HCWs from tertiary hospitals.Conclusions HCWs in Shanghai were highly immune to measles.However,HCWs with unknown immunization history should be vaccinated with measles containing vaccine,especially new HCWs,nursing workers and medical students.Coverage of measles-rubella or measles-mumps-rubella combined vaccine among HCWs in secondary and tertiary hospitals should be also improved to prevent rubella and mumps.更多还原