【摘要】 目的报告一起学校流行性脑脊髓膜炎(流脑)爆发疫情的病原学特征。方法对疑似流脑病例进行流行病学调查,采集患者脑脊液和血标本及首例病例密切接触者咽拭子标本,进行病原学分离鉴定、实时荧光定量聚合酶链反应(Polymerase Chain Reaction,PCR)检测和多位点序列分型(Multi-locus Sequence Typing,MLST)分析。结果该起流脑爆发疫情由C群脑膜炎奈瑟菌引起,MLST分型为ST-4821高致病克隆群。结论该起疫情由C群脑膜炎奈瑟菌ST-4281引起,该克隆群为中国独有的高致病基因群,本结果有利于制定全省流脑防控策略。更多还原

【Abstract】 Objective To identify the characteristics of the pathogen in an outbreak of epidemic cerebrospinal meningitis(ECM) in a school.Methods Suspected cases of ECM were investigated epidemiologically;blood and cerebrospinal fluid samples were collected from patients;and throat swabs samples were collected from close contacts of the first patient.The samples were tested for pathogen isolation and identification.Isolates were tested using real time polymerase chain reaction(PCR) and multi-locus sequence typing(MLST).Results The outbreak was caused by serogroup C Neisseria meningitides.MLST showed that it was ST-4281,a highly pathogenic gene group.Conclusions The outbreak of ECM was caused by the ST-4281 gene group of serogroup C Neisseria meningitides.This result can help develop ECM prevention and control strategies in Guizhou province.更多还原