Background and purpose: Cancer of unknown primary(CUP) represents approximately 5%~10% of malignant neoplasms. For CUP patients, identification of tumor origin allows for more specific therapeutic regimens and improves outcomes. Methods: By retrieving the gene expression data from Array Express and Gene Expression Omnibus data repositories, we established a comprehensive gene expression database of 5 800 tumor samples encompassing 22 main tumor types. The support vector machine-recursive feature elimination...
【更新日期】
2016-12-07
【分类号】
R730.43
【正文快照】
Identification and validation of a novel gene expression signature for diagnosing tumor tissue originWANG Qifeng1,XU Qinghua2,CHEN Jinying2,QIAN Chenhui2,LIU Xiaojian3,DU Xiang1(1.Departmentof Pathology,Fudan University Shanghai Cancer Center,Department o
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