【摘要】 目的探讨血液中N末端B型利钠肽原(NT-pro BNP)对非ST段抬高型急性冠状动脉综合征(NSTE-ACS)危险分层的价值。方法选取2012年1月~2013年12月间我科94例NSTE-ACS患者分为高危NSTE-ACS组52例(高危UAP22例,NSTEMI30例)和非高危NSTE-ACS组42例[低危UAP20例,中危UAP 22例];将具有胸痛症状且经冠状动脉CT造影(CCTA)证实为阴性的患者为对照组,共38例。入院后即刻采集静脉血同时检测NTpro BNP、高敏肌钙蛋白T(hs-c Tn T)浓度,比较各组间NT-pro BNP、hs-c Tn T浓度的变化,并分析其相关性。结果高危NSTE-ACS组NT-pro BNP、hs-c Tn T浓度均高于非高危NSTE-ACS组,差异有统计学意义(P<0.01),经Pearson直线相关分析,高危NSTE-ACS组NT-pro BNP浓度与hs-c Tn T浓度呈正相关(r=0.92,P<0.001);非高危NSTEACS组NT-pro BNP浓度与hs-c Tn T浓度亦呈正相关(r=0.83,P<0.001)。结论 NT-pro BNP是心肌缺血损伤的可靠指标,可作为NSTE-ACS危险分层的依据。更多还原

【Abstract】 Objective To study of the N-terminal pro-brain B-type natriuretic peptide(NT-pro BNP)in the risk stratifi cation value of non-ST segment elevation acute coronary syndrome(NSTE-ACS ACS). Methods 94 patients with NSTE-ACS in January 2012 to December 2013 were divided into high-risk NSTE-ACS group(52 patients) including22 patients with high-risk unstable angina pectoris(high-risk UAP),30 patients with non-ST segment elevation acute myocardial infarction(NSTEMI),and non-high-risk NSTE-ACS group(42 patients) including 20 patients with low-risk UAP and 22 patients with middle-risk UAP;38 patients with noncardiac chest pain by coronary computed tomography angiography(CCTA) was control group. By collecting venous blood and detecting concentration of NT-pro BNP and high sensitive troponin T(hs-c Tn T) of patients with NSTE-ACS, concentration of NT-pro BNP and hs-c Tn T of patients with NSTE-ACS in each group was compared and their correlation was analyzed. Results Concentration of NT-pro BNP and hs-c Tn T was higher in high-risk NSTE-ACS group than in non-high-risk NSTE-ACS group(P<0.001); concentration of NT-pro BNP positively correlated with hs-c Tn T level in high-risk NSTE-ACS group(r=0.92,P<0.001) by Pearson rectilinear correlation analysis,so in non-high-risk NSTE-ACS group(r =0.83,P <0.001). Conclusion NT-pro BNP is reliable indicator of myocardial ischemia and injury,and is on the basis of risk stratification in patients with NSTE-ACS.更多还原