【摘要】 目的探讨冠心病合并抑郁患者血小板参数检测的临床意义。方法选取2012年9月~2013年6月就诊于我院心内科并确诊为冠心病患者144例,通过汉密尔顿抑郁量表(hamilton depression scale,HAMD)进行抑郁评分,分为非抑郁组(n=117)与抑郁组(n=27),采用血液自动分析仪器LH750(BECKMAN,USA)测定患者外周血中血小板计数(PLT)、血小板平均体积(MPV)、血小板体积分布宽度(PDW)及血小板压积(PCT)。结果抑郁组患者PLT较非抑郁组低,差异有统计学意义[(178.59±42.96)×10~9/L vs(213.70±47.08)×10~9/L,P<0.05)],MPV较非抑郁组高,差异有统计学意义[(11.77±1.05)% vs(10.05±0.94)%,P<0.05)];两组间PDW、PCT、血脂等指标比较,差异无统计学意义(P>0.05)。结论冠心病合并抑郁患者MPV水平较非抑郁患者高,是冠心病合并抑郁的危险因素,我们需要关注冠心病合并抑郁患者血小板功能检测。更多还原

【Abstract】 [Absract] Objective To investigate the clinical significance of platelet parameters in patients with coronary heart disease and depression. Methods 144 patients with coronary heart disease, who had undergone coronary angiography from September 2012 to June 2013, were included in this study. These patients were divided into two groups according to the HAMD depression scores depression group(n=27), non-depressed group(n=117). The detection of PLT, MPV, PDW and PCT were compared by multi-parameter automated hematology analyzer LH750(BECKMAN, USA). Results Patients with depression had greater mean platelet volume levels[(11.77±1.05)% vs(10.05±0.94)%,P<0.05)] and lower blood platelet count, the differences were statistically significant[(178.59±42.96)×10~9/L vs(213.70±47.08)×10~9/L, P<0.05). There were no statistically significant differences on PDW, PCT and lipid indexes between depression group and non-depressed group(P>0.05). Conclusion According to the findings of this study, increased MPV is one of the risk factors of developed depressive symptoms in patients with coronary heart disease. We should pay more attention on the association of blood-platelet parameters with depression in coronary heart disease patients.更多还原