【摘要】 目的探讨妊娠合并乙型肝炎患者主要肝功能指标与血清HBV-DNA水平之间的相关性。方法选取2014年11月~2015年10月医院诊治的40例妊娠合并乙型肝炎患者资料进行分析,患者入院后采用荧光定量PCR方法检测患者血清中的HBV-DNA水平,采用ELISA检测乙型肝炎五项指标,利用全自动生化分析仪检测主要肝功能指标,分析妊娠合并乙型肝炎患者主要肝功能指标与血清HBV-DNA水平之间的相关性。结果入选的40例患者中以HBV-DNA拷贝系数≤1.0×10~4为主,占55%,且血清表型主要以1、4、5为主。其次为HBVDNA拷贝系数>1.0×10~5,占35%,血清表型主要以1、3、5为主;对于DNA拷贝数>1.0×10~5患者谷丙转氨酶、谷草转氨酶以及转肽酶水平以及总胆汁酸水平,显著高于DNA拷贝数为1.0×10~4~1.0×10~5以及DNA拷贝数≤1.0×10~4患者(P<0.05)。结论妊娠合并乙型肝炎患者中主要肝功能指标与血清HBV-DNA呈现出正相关性。且高血清HBV-DNA拷贝数妊娠合并乙型肝炎患者主要以大三阳为主,能够辅助衡量肝脏炎症情况。更多还原

【Abstract】 Objective To investigate the correlation between primary liver function indexes and serum HBV-DNA level in pregnant patients with hepatitis B. Methods Materials of 40 pregnant patients with hepatitis B who were admitted to our hospital from November 2014 to October 2015 were selected and analyzed. Serum HBV-DNA level were examined by fluorescence quantitative PCR and the 5 indexes of hepatitis B were examined by ELISA after the admission. Primary liver function indexes were monitored by automatic biochemistry analyzer and the correlation between primary liver function indexes and serum HBV-DNA level in pregnant patients with hepatitis B were analyzed. Results HBV-DNA copy coefficient ≤1.0×10~4was predominant in the selected 40 cases, accounting for 55% with 1, 4 and 5 as the predominant serum phenotype. The second one was HBV-DNA copy coefficient >1.0 ×10~5, accounting for 35% with 1, 3and 5 as the predominant serum phenotype. Patients with DNA copy coefficient >1.0×10~5had significant higher level of glutamic-pyruvic transaminase, glutamic oxalacetic transaminase, transpeptidase and total bile acid than patients with DNA copy coefficient 1.0×10~4-1.0×10~5and ≤1.0×10~4(P<0.05). Conclusion Primary liver function indexes present positive correlation with serum HBV-DNA level in pregnant patients with hepatitis B. Pregnant patients with hepatitis B and high DNA copy coefficient should take "great three positive" as predominant factor that can be helpful in measuring the condition of hepatitis.更多还原