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氯吡格雷联合阿托伐他汀治疗急性脑梗死的疗效及对血清hs-CRP的影响
Effect of clopidogrel combined with atorvastatin in treatment of acute cerebral infarction and its effect on serum hs-CRP
【摘要】 目的观察氯吡格雷联合阿托伐他汀治疗急性脑梗死的疗效,以及二者联用后急性脑梗死患者hs-CRP的变化情况。方法选择2012年1月~2015年1月在我院治疗的急性脑梗死患者100例作为研究对象,两组患者均予改善循环、控制血压、血糖、抗血小板聚集、维持水电解质平衡等常规对症治疗,观察组在此基础上给予氯吡格雷联合阿托伐他汀治疗,两组均治疗2周。结果观察组基本痊愈率达30.0%,总有效率96.0%,对照组基本痊愈率达24.0%,总有效率76.0%,两组疗效比较,差异具有统计学意义(P<0.05)。观察组与对照组治疗前的hs-CRP水平分别为(13.14±1.36)mg/L、(12.82±1.23)mg/L,治疗14 d后,观察组与对照组hs-CRP水平分别为(7.91±1.23)mg/L、(9.34±1.07)mg/L,两组治疗后组间比较,差异具有统计学意义(P<0.05)。结论氯吡格雷联合阿托伐他汀治疗急性脑梗死可以提高疗效,考虑可能与二者联用通过降低血清hs-CRP水平而发挥抗炎作用有关。
【Abstract】 Objective To observe the clinical effect of clopidogrel combined with atorvastatin in the treatment of acute cerebral infarction, and the changes of hs-CRP in two patients with acute cerebral infarction. Methods A total of 100 cases of acute cerebral infarction treated in our hospital from January 2012 to January 2015, two groups were treated with improved circulation, control blood pressure, blood glucose, anti platelet aggregation, maintenance of water electrolyte balance and other conventional symptomatic treatment. The observation group was treated with clopidogrel combined with atorvastatin treatment, the two groups were treated for 2 weeks. Results The recovery rate of the observation group was 30.0%, the total effective rate was 96.0%, the control group was 24.0%, the total effective rate was 76.0%,and the efficacy of the two groups was significant(P<0.05). The hs-CRP levels of the observation group and the control group were(13.14±1.36)mg/L,(12.82±1.23)mg/L, 14 days after treatment, the hs-CRP levels of the observation group and the control group were(7.91±1.23)mg/L,(9.34±1.07)mg/L, the two groups were compared with the control group,the difference was significant(P<0.05). Conclusion Clopidogrel combined with atorvastatin can improve the curative effect of acute cerebral infarction, which may be associated with the combination of them with anti-inflammatory effects by decreasing hs-CRP levels.
【Key words】 Acute cerebral infarction; Atorvatatin; Clopidogrel; hs-CRP;
- 【文献出处】 中国现代医生 ,China Modern Doctor , 编辑部邮箱 ,2016年05期
- 【分类号】R743.3
- 【被引频次】9
- 【下载频次】35