【摘要】 目的探讨不一致性淋巴瘤的临床病理学特征。方法结合临床、影像学、HE形态、免疫组化和分子病理学对1例不一致性腋窝弥漫性大B细胞淋巴瘤(DLBCL)和鼻咽、左颈部血管免疫母细胞性T细胞淋巴瘤(AITL)进行临床病理分析,并复习相关文献。结果患者以全身浅表淋巴结肿大为首发症状,腋窝淋巴结活检诊断为DLBCL,未作任何治疗。4年后发现鼻咽部新生物,活检提示T细胞性淋巴瘤,化疗2个疗程;5个月后出现全身浅表淋巴结肿大伴腹腔淋巴结肿大,活检左颈部淋巴结诊断为AITL;结合免疫组化、基因重排和EBER检测确诊为不一致性腋窝弥漫性大B细胞性淋巴瘤和鼻咽、左颈部血管免疫母细胞性T细胞性淋巴瘤。结论不一致性淋巴瘤罕见,早期很难明确诊断,易误诊而影响临床治疗导致预后不佳。更多还原

【Abstract】 Purpose To explore the clinicopathologic features of discordant lymphoma. Methods A case of discordant lymphoma comprised of diffuse large B-cell lymphoma( DLBCL) and angioimmunoblastic T cell lymphoma( AITL) was studied by imaging,histopathology,immunohistoehemistry and molecular pathology,and the related literatures were reviewed. Results The patient had Lymph node in axillary and the first diagnosis was DLBCL and untreated. Four years later,the patient had a neoplasm in nasopharynx and showed a feature of T-cell lymphoma. The patient was treated with chemotherapy for two times. Five mouths later,the patient had enlarged lymph node in superficial and abdominal and the diagnosis was AITL. The final diagnosis of the patient was discordant lymphoma simultaneously comprised of diffuse large B-cell lymphoma and angioimmunoblastic T cell lymphoma. Conclusion Discordant lymphoma is extremely rare and diverse. It is difficult to diagnoze this tumor in the early stage. Misdiagnosis and improper treatment result in poor prognosis of patients.更多还原