AIM: To test the telomere length of peripheral blood leukocytes in the patients with type 1 diabetes mellitus( T1DM),type 2 diabetes mellitus( T2DM) and T2DM complicated with arterial sclerosis( DAS),and to explore the related mechanism. METHODS: Thirty patients with T1 DM,60 patients with T2DM,40 patients with DAS and 40 normal controls( NC group) were enrolled in this trial and the peripheral blood leukocytes were isolated to extract DNA for determining telomere length by real-time PCR. Multiple linear re...
【基金】
国家自然科学基金资助项目(No.81272444;No.81472744)
【更新日期】
2016-07-20
【分类号】
R587.1;R543.5
【正文快照】
diabetic patients is mainly associated with age,duration of illness,and BMI.端粒是由2位著名的遗传学家Mc Clintock[1]与Muller[2]最早提出来的,他们发现染色体的稳定性和完整性是由染色体的末端来维持的,并且Muller[2]将其命名为“telomere”。端粒是非常特殊的DNA结构,
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