【摘要】 系统性红斑狼疮(SLE)是一种病因不明的慢性自身免疫性疾病,可导致多系统的损害。本病目前治疗手段有限,多数药物作用机制为针对患者的免疫应答失衡。合成肽作为一种新型药物,靶向作用于狼疮发病机制相关细胞表面的特定抗原,因此具有针对性强、副作用少的优点。合成肽具有诱导免疫耐受的作用,并且可改善小鼠模型中该疾病的临床表现。本文对合成肽治疗系统性红斑狼疮的临床前研究和作用机制作一综述。更多还原

【Abstract】 Systemic lupus erythematosus(SLE) is a chronic autoimmune disease with unknown etiology,which can cause multi-organ damages. Therapeutic approaches are still limited although various immunomodulators are available to improve the imbalanced immune responses. However,synthetic peptides can serve as antigenic epitopes,targeting specific antigens on the surface of cells which are associated with the pathogenesis of SLE. Due to their high specificity,synthetic peptides exhibit fewer side effects. Synthetic peptide can induce immune tolerance and improve clinical symptoms of SLE in murine model. In this review we give an overview on the preclinical study of synthetic peptides in treating SLE and the underlying mechanisms.更多还原