A 49-year-old male suffered from erythemas and desquamation all over the body,without pruritus for one year. He had been diagnosed with eczema and exfoliative dermatitis. Disease exacerbated after temporary relief with glucocorticoids treatment. Skin examination showed extensive erythemas over the trunk and the distal extremities,especially in the interdigits,forearms,inguen and around the navel. Various inflammatory papules and papulovesicles,accompanied by a large number of bran-like scales and thick crus...