【摘要】 目的探讨胃癌p53、nm23和cerbB-2的表达与其预后关系。方法用免疫组化方法测定胃癌标本中p53、nm23、cerbB-2癌基因编码蛋白表达,并统计患者的临床数据。结果p53和cerbB-2的过表达以及nm23的低表达在胃癌的TNM分期、分化程度、肿瘤浸润程度、淋巴结转移率、5年生存率上有统计学差异。结论联合测定p53、nm23、cerbB-2癌基因编码蛋白表达比单独测定单一指标更有价值,可作为评估胃癌患者预后的重要指标。更多还原

【Abstract】 Objective To investigate the relation between the expression of p53, nm23, cerbB-2 in gastric cancer and prognosis. Methods To detect p53,nm23, cerbB-2 gene protein in gastric cancer by immunohistochemistry. Collect the patients’ clinical data. Results Hypo-expression of nm23, hyperexpression of p53 and cerbB-2 had statistically significant difference in differentiation of gastric cancer, lymph node metastasis rate, tumor infiltrating degree, TNM stagings, 5-year survival rates. Conclusion Combined detection of nm23, p53 and cerbB-2 was important index of prognosis, which had more positive effects than anyone individually.更多还原