【摘要】 目的回顾性分析冠心病合并糖尿病死亡患者代谢异常特征。方法采用病例对照法,选取2006年11月-2016年3月近十年间在北京安贞医院心内科住院的冠心病合并糖尿病死亡患者52例为病例组,冠心病无糖尿病死亡患者52例为对照组。所有入选患者以心血管疾病为首要死因且病案资料完整,组间性别及年龄均匹配。比较一般资料及代谢性指标如总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、空腹血糖、糖化血红蛋白、血尿酸等。结果冠心病合并糖尿病死亡患者冠心病病程、吸烟史、住院次数及血脂异常与对照组相比,差异有统计学意义(P<0.05);空腹血糖、糖化血红蛋白与对照组相比,差异有统计学意义(P<0.01);血脂代谢指标中仅甘油三酯水平与对照组相比,差异有统计学意义(P=0.01)。结论血糖及甘油三酯水平升高是冠心病合并糖尿病死亡患者的主要代谢异常特征。更多还原

【Abstract】 Objective To retrospectively analyze the characters of metabolism in patients died of coronary artery disease(CAD) who complicated diabetes mellitus(DM). Methods A total of 52 cases with CAD and DM(CADDM) as case group and 52 CAD patients without DM(CAD-NDM) as the control group were enrolled in this casecontrol study in Beijing Anzhen Hospital between November 2006 to March 2016. Two groups were matched for sex and age. Clinical and demographic date were collected. Metabolic parameters such as total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, fasting blood glucose, glycosyl ated hemoglobin, serum uric acid and coronary artery lesions betweem two groups were compared. Results The disease course of CAD, smoking, dyslipidemia and number of hospitalizations were significant different(P<0.05) between CAD- DM group and CAD- NDM group. The differences of fasting blood glucose and glycosylated hemoglobin between the two groups were statistically significant(P<0.001). In blood lipid, the significant difference was only been observed in triglyceride(P=0.011). Conclusions The increased blood glucose and triglycerides are the main characteristics of metabolic disorders in patients died of coronary artery disease and diabetes mellitus.更多还原