【摘要】 目的探讨慢性阻塞性肺病(COPD)急性加重期胆碱酯酶和降钙素原的水平变化。方法选取2014年3月—2016年2月青岛市第八人民医院收治的127例慢性阻塞性肺病急性加重期患者作为观察组,选取100例同期健康体检者作为对照组,观察2组血清中胆碱酯酶(CHE)、降钙素(PCT)水平;对观察组患者进行吸氧、化痰、平喘、改善通气、抗感染等常规治疗,并加用痰热清注射液20 ml加入5%葡萄糖注射液中静脉输注,1次/d,7 d为1个疗程。比较治疗前后患者血清中CHE、PCT水平的变化。采用SPSS19.0统计学软件及t检验分析数据。P<0.05为差异有统计学意义。结果 COPD急性加重期患者血清中CHE水平低于对照组,PCT水平高于对照组,差异均有统计学意义(P<0.05);治疗后COPD急性加重期患者血清中CHE水平高于治疗前,PCT水平低于治疗前,差异有统计学意义(P均<0.05)。结论 COPD急性加重期患者血清CHE水平降低,PCT水平升高;治疗后CHE水平升高、PCT水平降低。更多还原

【Abstract】 Objective To investigate the changes of levels of cholinesterase and procalcitonin in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods Totally 127 patients with acute exacerbation of chronic obstructive pulmonary disease were selected from March 2014 to February2016 in the eighth people’s hospital of Qingdao as the observation group,100 patients with healthy volunteers as a control group.Serum levels of alkaline esterase,calcitonin in two groups were observed.Patients in observation group were treated with conventional therapy,such as oxygeninhalation,resolving sputum and relieving asthma,improving ventilation,and other conventional anti-infective therapy,meanwhile,adding the Tanreqing 20 ml mixed into 5% glucose injection by intravenous infusion,once a day,7d as a course of treatment.Then we compare the levels of CHE and PCT before and after treatment,using SPSS 19.0 statistical analysis software and t test to analyze the data.P<0.05 was considered statistically significant.Results Compared with the control group,serum CHE levels in observation group were increased,but PCT levels were decreased,the difference was statistically significant(P<0.05).The CHE level in patients with acute exacerbation of chronic obstructive pulmonary disease were higher after treatment than before treatment,but the PCT level was lower,the difference was statistically significant(all P<0.05).Conclusions Serum level of CHE in patients with acute exacerbation of chronic obstructive pulmonary disease is decreased,but the PCT level is increased,they are all improved after treatment.更多还原