【摘要】 目的:探讨果糖注射液对慢性乙型肝炎(chronic hepatitis b,CHB)合并2型糖尿病(type 2 diabetes,T2DM)患者血糖的影响。方法:71例CHB合并T2DM患者按随机数字表法分为观察组(33例)和对照组(38例),观察组患者接受以10%果糖注射液250 ml作为甘草酸类制剂的溶剂静脉滴注,对照组接受以5%葡萄糖注射液250 ml加入3 U胰岛素作为甘草酸类制剂的溶剂静脉滴注,在静脉滴注前、静脉滴注完毕、静脉滴注完毕后1.5 h,测患者血糖,连续测定3 d。结果:静脉滴注过程中,观察组和对照组患者血糖均值呈上升趋势,静脉滴注后与静脉滴注后1.5 h基本保持平稳,2组患者不同时间点血糖变化比较,差异无统计学意义(P>0.05);用药过程中未发现与果糖相关的不良反应。结论:果糖注射液对CHB合并T2DM患者的血糖变化无影响,值得临床推广。更多还原

【Abstract】 OBJECTIVE: To investigate the effects of fructose injection on chronic hepatitis B(CHB) combined with type 2 diabetes mellitus( T2DM).METHODS: 71 cases of CHB combined with T2 DM were divided into observation group(33 cases) and control group(38 cases) via the random number table.The observation group were treated with 10% fructose injection 250 ml as menstruum of glycyrrhizin,while the control group received 5% glucose injection 250 ml with 3 U insulin as menstruum of glycyrrhizin.Before infusion,after infusion and after infusion of1.5h,the level of blood glucose in patients were determined for 3 d.RESULTS: During intravenous infusion,the level of blood glucose in both observation group and control group increased significantly,and maintained steady basically after infusion and after infusion of 1.5 h; with no significant difference in blood glucose between the observation group and the control group( P > 0.05).There were no adverse drug reactions related to fructose had been found during the treatment course.CONCLUSIONS: Fructose injection has no effects on the level of blood glucose in patients with chronic hepatitis B and type two diabetes mellitus.It is worthy of clinical application.更多还原