【摘要】 目的评价多索茶碱对双腔气管插管单肺通气患者术中肺功能的影响。方法择期双腔气管插管全身麻醉下行开胸肺叶切除术患者50例,采用随机数字表法分为对照组（C组）和多索茶碱组（D组）（n=25）。D组于双腔气管插管后静脉输注多索茶碱4 mg·kg^-1;C组静脉输注等量0.9%氯化钠注射液。麻醉维持采用靶控输注全凭静脉麻醉。于给药前即刻（t₀）、开胸单肺通气30 min时（t₁）、60 min时（t₂）及关胸膨肺后双肺通气时（t₃）,采集动脉血2 mL行血气分析,记录二氧化碳分压（PaCO₂）及氧分压（PaO₂）,记录各时间点气道峰压（Ppeak）、气道平台压（Pplat）、气道阻力（Raw）及肺顺应性（Compl）。结果与C组比较,D组患者t₁^t₃时Ppeak、Pplat及Raw降低,Compl及PaO₂升高（P<0.05）;与t₀时比较,t₃时C组患者Ppeak、Pplat及Raw升高,Compl及PaO₂降低（P<0.05）。结论多索茶碱可改善双腔气管插管单肺通气患者术中肺功能。更多还原

【Abstract】 Objective To evaluate the effects of doxofyline on intraoperative pulmonary function in patients receiving double lumen endotracheal intubation for one-lung ventilation. Methods Fifty patients who underwent elective pulmonary lobectomy under general anesthesia using double lumen endotracheal intubation were randomly divided into two groups（ n = 25each） : control group（ group C） and doxofyline group（ group D）. Doxofyline( 4 mg · kg^-1) was injected intravenously after double lumen endotracheal intubation in group D,while equal volume of 0.9% sodium chloride was intravenously given in group C.Total intravenous anesthesia with target controlled infusion was performed during the operation.Two milliliter blood samples were taken from the radial artery for blood gas analysis immediately before administration（ t₀）,at 30 min（ t₁）,60 min（ t₂） after onelung ventilation and at the moment of two-lung ventilation after chest closing（ t₃）. The Pa CO2,Pa O2,peak airway pressure（ Ppeak）,airway plateau pressure（ Pplat）,airway resistance（ Raw） and lung compliance（ Compl） were recorded at t₀-3. Results The Ppeak,Pplatand Rawwere significantly decreased and the Compland PaO₂ significantly increased at t₁-t₃ in group D when compared with those in group C（ P<0.05）. The Ppeak,Pplatand Rawwere significantly increased and Compland PaO₂ significantly decreased at t₃ as compared with those at t₀ in group C（ P<0.05）. Conclusion Doxofyline can improve intraoperative pulmonary function in patients who undergo double lumen endotracheal intubation for one-lung ventilation.更多还原