【摘要】 目的观察大株红景天注射液对周围型肺癌（PLC）肺叶切除术后疲劳综合征（POFs）的影响。方法将2014年11月²016年2月十堰市太和医院呼吸内科收治的106例PLC患者随机分为对照组、观察组。对照组行全胸腔镜肺叶切除术（VATS）治疗,观察组VATS术后静滴大株红景天注射液,20 mg/d。采用经颅多普勒（TCD）监测VATS术前1 d和治疗第7、14天大脑皮层电位及肌电图,分析静脉血氧饱和度（SpO₂）,外周血5-羟色胺（5-HT）、肾上腺素（Adr）、去甲肾上腺素（NE）水平。采用简明心境量表（BPOMS）评定围术期患者心境状态,采用视觉模拟评分（VAS）量表评价疲劳程度,并统计术后肺部并发症和临床疗效。结果治疗第7、14天时,观察组大脑皮层电位[（138.19±15.39）、（97.89±12.24）μV]及肌电图[（94.37±8.99）、（86.99±7.02）μV]均较对照组[（167.21±17.81）、（125.37±15.21）μV;（125.02±13.92）、（107.17±9.72）μV]显著下降,差异均有统计学意义（均P<0.05）。治疗第14天时,观察组外周血5-HT水平[（8.09±2.12）ng/m L]较对照组[（12.02±4.20）ng/m L]显著下降（P<0.05）,Sp O2[（99.07±1.34）%]较对照组[（95.34±1.36）%]显著升高（P<0.05）。治疗第7、14天时,观察组BPOMS[（20.91±3.95）、（10.54±2.01）分]和VAS[（5.37±0.23）、（3.04±0.22）分]评分均较对照组[（27.12±4.02）、（16.58±2.74）分;（7.81±0.31）、（5.74±0.25）分]显著下降（均P<0.05）。观察组并发症发生率（18.87%）显著低于对照组（33.96%）（P<0.05）。观察组愈显率（84.91%）和总有效率（96.23%）均明显高于对照组（67.92%、86.79%）,差异均有统计学意义（均P<0.05）。结论大株红景天注射液对PLC肺叶切除术后POFs具有防治作用。更多还原

【Abstract】 Objective To observe the effects of Sofren Injection on postoperative fatigue syndrome（POFs） in patients with peripheral lung cancer（PLC） after pulmonary lobectomy surgery.Methods One hundred and six patients with PLC admitted to Department of Respiratory Medicine,Taihe Hospital of Shiyan City from November 2014 to February 2016 were randomly divided into the control group and the observation group.The control group was taken video-assisted thoracoscopic surgery（VATS）,the observation group was injected with Sofren（20 mg/d） after VATS surgery.The transcranial Doppler（TCD） was used to monitor the cortical potentials and electromyogram one day before the VATS,as well as on the 7th and 14 th day after the VATS.The levels of venous oxygen saturation（Sp O2）,5-hydroxytryptamine（5-HT）,adrenaline（Adr） and noradrenaline（NE） were also analyzed;the brief profile of mood states（BPOMS） was adopted to assess the state of mind;while the visual analogue scale（VAS） was used to evaluate the degree of fatigue,the postoperative pulmonary complications and clinical efficiency were recorded as well.Results On the 7th and 14thday of treatment,the cortical potentials [（138.19±15.39）,（97.89 ±12.24） μV] and electromyogram [（94.37 ±8.99）,（86.99 ±7.02） μV] in the observation group were remar kably decreased compared with those of control group[（167.21 ±17.81）,（125.37 ±15.21） μV;（125.02 ±13.92）,（107.17 ±9.72） μV],the differences were all statistically significant（all P < 0.05）.On the 14 th day of treatment,the level of peripheral blood 5-HT in the observation group [（8.09±2.12） ng/m L] was significantly reduced compared with that of control group [（12.02±4.20） ng/m L]（P < 0.05）,furthermore,SpO₂ of the observation group [（99.07±1.34）%] was distinctly increased compared with that of the control group[（95.34±1.36）%]（P < 0.05）.On the 7th and 14 th day of treatment,the scores of BPOMS [（20.91±3.95）,（10.54±2.01）points] and VAS [（5.37±0.23）,（3.04±0.22） points] in the observation group were all decreased remarkably compared with those of control group [（27.12 ±4.02）,（16.58 ±2.74） points;（7.81 ±0.31）,（5.74 ±0.25） points]（P < 0.05）;the incidence of complications in the observation group（18.87%） was significantly lower than that of control group（33.96%）（P< 0.05）;the cured and markedly effective rate（84.91%） and total effective rate（96.23%） in the observation group were also all significantly higher than those of control group（67.92%,86.79%）,the differences were all statistically significant（all P < 0.05）.Conclusion Sofren Injection has preventive effect for the POFs in patients with PLC after pulmonary lobectomy.更多还原